新辅助化疗治疗局部晚期宫颈癌27例临床观察  

Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancinoma:Clinical Observation in 27Cases

作　　者：王燕[1] 

机构地区：[1]淮南市第一人民医院妇产科,安徽淮南市232007

出　　处：《中国民族民间医药》2009年第8期35-36,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:评价Ⅰb2～Ⅱb期局部晚期宫颈癌于根治术前给予新辅助化疗的疗效。方法:27例Ⅰb2～Ⅱb期局部晚期宫颈癌,术前采用1-3个疗程的静脉化疗,之后全部行宫颈癌根治术。通过观察患者病灶大小的改变、化疗毒副反应、术中情况、术后病理反应等,评价新辅助化疗在宫颈癌治疗中的作用及安全性。结果:化疗总有效率79.8%(21/27),完全缓解率为7.4%(2/27)。化疗毒副反应轻微。所有患者化疗后均进行了广泛性子宫切除术及盆腔淋巴清扫术。结论:Ⅰb2～Ⅱb期局部晚期宫颈癌在根治术前给予静脉滴注化疗能使肿瘤缩小,宫旁组织浸润消退,为根治性手术创造条件。Objective：To investigate the clinical effect of neoadjuvant chemotherapy on cervical cancer in stage I b2-II b.Methods：27patients with locally advanced cervical cancer were treated with a 1-3 course of neoadjuvant chemotherapy,and then underwent radical surgery in all of them.The effect and safety of chemotherapy in the treatment of cervical cancer were evaluated by the lesion size,toxic side effects,operative status,and pathology Results：The effective rate of chemotherapy was 79.8% with 2 cases of total complete remission. Toxic side effects were weak. After neoadjunct chemotherapy, all of these patients were performed radical hysterectomy and pelvic lyrrphorectomy. Conclusion： Preoperative intravenous infusion as neoedjuvant chemotherapy is effective in cervical and parametrical regression ,and thus more satisfactory operative results attained.

关 键 词：宫颈癌 新辅助化疗 宫颈癌根治术 

分 类 号：R737.33[医药卫生—肿瘤]