乳腺癌HLA-DR表达及其临床价值  

Clinical significance of HLA DR antigen expression in breast cancer

作　　者：程伏林[1,2] 杨国梁[1,2] 李培云[1,2] 唐芝姣[1,2] 

机构地区：[1]湖北医科大学附属第二医院肿瘤研究所 [2]湖北医科大学病理教研室

出　　处：《实用肿瘤杂志》1998年第4期208-211,共4页Journal of Practical Oncology

摘　　要：采用免疫组化技术，分析了４０例乳腺癌石蜡标本主要组织相容性抗原ＨＬＡ－ＤＲ与各项临床病理参数和生存预后的关系。根据ＨＬＡ－ＤＲ阳性细胞的多少，４０例病人分成两组：高阳性组（ＧＨ，＞３０％）和低阳性组（ＧＬ，≤３０％）。结果显示：①ＨＬＡ－ＤＲ表达与原发灶大小、淋巴结转移数、ＴＮＭ分期、组织学分级无关，但与癌周淋巴细胞浸润显著相关（Ｐ＜０．０５）；②高阳性组各时点生存率及总体生存率均显著高于低阳性组（Ｐ＜０．０５）。资料提示。We studied 40 cases of breast cancer to examine the correlation of HLA DR antigen expression on tumor tissues with clinicopathological features.Immunohistochemistry was preformed by using a monoclonal antibody specifically against HLA DR.All tumor tissues were divided into two groups,depending on the rate of HLA DR positive cells(greater and lesser than 30%).The result showed that HLA DR expression was not associated with such clinicopathological parameters as tumor size,axillary lymth node metastasis,clinical TNM stage and histologic grade,but it was associated with peripheral lymphocyte infiltration.The group with high HLA DR expression(GH) demonstrated significantly better survival in comparison with the group with low expression(GL).We speculate that HLA DR expression in breast cancer cells exerts a favorable influence on clinical course.

关 键 词：乳腺癌 病理学 HLA-DR 免疫组织化学 

分 类 号：R737.902[医药卫生—肿瘤]