乳腺良恶性病变组织中c-myc和TGF-β_1表达及意义  

Expressions and Significance of c-myc Oncoprotein,TGF-β 1 in Malignant and Benign Lesions of Breast

作　　者：喻梅英[1] 杨竹林[1] 陈显玉[1] 黄忠诚[1] 文继舫[2] 

机构地区：[1]湖南医科大学附属第二医院 [2]湖南医科大学病理学教研室

出　　处：《湖南医学》1998年第4期195-197,共3页Hunan Medical Journal

摘　　要：应用ＡＢＣ免疫组化法研究５０例乳腺癌和１２例乳腺良性病变组织中ｃ－ｍｙｃ蛋白和ＴＧＦ－β１表达及意义。ｃ－ｍｙｃ蛋白、ＴＧＦ－β１在乳腺癌和良性病变中阳性表达率分别为５６％，３６％和９１１％，６６７％；ｃ－ｍｙｃ蛋白阳性率在乳腺癌和良性病变中有显著差异（Ｐ＜００５）；乳腺癌Ⅰ级、无淋巴结转移和肿块最大径≤３ｃｍ者ｃ－ｍｙｃ和ＴＧＦ－β１阳性率均明显低于有淋巴结转移，肿块＞３ｃｍ以上的Ⅲ级病例，但与乳腺癌内分泌状态无明显关系。结果提示ｃ－ｍｙｃ蛋白和ＴＧＦ－β１在乳腺癌发生、发展。The expressions and biological significance of c-myc oncoprotein and transforming growth factor-β 1(TGF-β 1) were studied by immunohistochemical method in 50 cases of breast cancer (BC) and 12 cases of benign lesions (BL).The positive rates of c-myc oncoprotein and TGF-β 1 were 56% and 36% respectively in BC, 91 1% and 66 7% respectively in BL. The expression of c-myc oncoprotein in BC and BL had a statistical difference (P<0 05). The positive rates of c-myc oncoprotein and TGF-β 1 were lower in the BC of histologic Grade I,without lymphonode metastasis,and maximun diameter of neoplasma >3cm than that of histologic Grade Ⅲ,with lymphonode metastasis, and maximun diameter of neoplasma ≤3cm. No correlations were found among the expressions of c-myc oncoprotein,TGF-β 1 and the endocrine state of BC. These results suggest that the c-myc oncoprotein and TGF-β 1 might have significance in carcinogenesis , development,biological behaviors and prognosis of BC.

关 键 词：乳腺肿瘤 C-MYC 转化生长因子Β 

分 类 号：R737.902[医药卫生—肿瘤]