鼻咽癌原发灶腔内微波热疗及CT观察  

Treatment of nasopharyngeal carcinoma with intracavitary hyperthermia and response observed by CT scan

作　　者：吴敬波[1,2] 陈成钦 钟强荣[1,2] 

机构地区：[1]泸州医学院附属医院肿瘤科 [2]广州中山医科大学肿瘤医院放疗科

出　　处：《中华放射肿瘤学杂志》1998年第2期101-104,共4页Chinese Journal of Radiation Oncology

摘　　要：目的探讨腔内微波热疗对鼻咽癌原发灶的作用。材料与方法１９９４年５月至１９９５年４月，９０例初治鼻咽癌病例分为热放组（腔内微波热疗＋放疗）与单放组（单纯放疗），同期配对分析，配对条件为年龄、性别、ＴＮＭ分期，根据治疗前后ＣＴ扫描评价近期疗效。两组均为常规连续放疗，剂量相同，热放组加用鼻咽腔内２４５０ＭＨｚ微波热疗，每周１～２次，每次加热６０分钟，肿瘤表面温度４１～５２℃。结果治疗后２～３个月ＣＴ复查热放组鼻咽癌原发灶肿瘤全消率６８．９％（３１／４５），单放组为４６．７％（２１／４５），Ｐ＜０．０５。肿瘤全消率与原发灶Ｔ分期、咽旁间隙受侵情况、肿瘤表面加热温度及热疗次数有关。结论腔内２４５０ＭＨｚ微波热疗配合放疗可提高鼻咽癌原发灶的近期肿瘤全消率。Purpose To evaluated the effect of intracavitary microwave hyperthermia for the primary lesion of nasopharyngeal carcinoma.Materials and Methods Ninty untreated NPC patients were treated from May 1994 to April 1995. They were divided into the combined group (intracavitary microwave hyperthermia plus irradiation)and the controlled group (radiotherapy alone) based on age,sex,and T,N,M system by case to case analysis.The effect of treatment was evaluated by CT scan.All patients in the two groups received the same conventional fraction radiation. The combined group was given intracavitary hyperthermia in the nasopharynx with a 2450 MHz microwave hyperthermia unit.The surface temperature of nasopharyngeal tumor ranged from 41℃ to 52℃,60 minutes per time,once or twice a week during radiotherapy.Results CT scan after 2～3 months followup showed that the CR rate of primary lesion in nasopharynx was 68.9%(31/45) in the combined group,as compared with 46.7%(21/45) in the controlled group (P<0.05).The effect of intracavitary hyperthermia was related to T stage,involvement of parapharyngeal space, surface temperature of tumor and time of thermotherapy.Conclusion The CR rate of primary lesion of NPC can be improved by intracavitary 2450 MHz microvave hyperthermia combined with radiotherapy.

关 键 词：鼻咽肿瘤 CT 微波疗法 

分 类 号：R739.630.5[医药卫生—肿瘤]