难治性贲门黏膜撕裂综合征加用奥曲肽疗效观察  

Study on the Effectiveness of Therapy with Octerotide in Patients with Intractable Mallory-Weiss Syndrome

作　　者：林海[1] 林志辉[1] 陈贻胜[1] 

机构地区：[1]福建医科大学省立临床学院消化内科,福州350001

出　　处：《临床消化病杂志》2009年第4期201-202,共2页Chinese Journal of Clinical Gastroenterology

摘　　要：目的观察奥曲肽对难治性贲门黏膜撕裂综合征(MWS)的疗效。方法将经常规治疗24h仍出血不止的47例MWS患者随机分为2组。治疗组(n=24)和对照组(n=23)。对照组:单用静脉注射奥美拉唑40mg,每12h1次。治疗组:加用奥曲肽(善宁)25μg/h微量泵泵入,连用3d。结果治疗组总有效率91.67%,明显优于对照组的73.91%(P<0.01)。结论对难治性MWS大出血患者,常规治疗效果不佳时,加用奥曲肽治疗效果显著。Objective To observe the effectiveness of therapy with octerotide in patients with intractable Mallory-Weiss syndrome （MWS）. Methods 47 MWS patients who did not respond to routine treatment at 24 h were randomly divided into two groups：the treatment group （ n = 24 ） and control group （ n = 23 ）. Patients in control group were only given 40 mg omeprazole injected intravenously ql2h. Patients in the treatment group were given the same drugs plus octerotide（somatostain） by continuous intravenous pump at a constant speed of 25μg/h for 3 days. Results The effective rate in treatment group was 91.67% , while that was 73.91% in control group （ P 〈 0. 01 ）. Conclusion Therapy with combing octerotide with omeprazole are more effective for treating MWS patients who do not respond to routine treatment.

关 键 词：奥曲肽 MALLORY-WEISS综合征 出血 

分 类 号：R573.2[医药卫生—消化系统]