慢性浅表性胃炎患者根除幽门螺杆菌后食管酸暴露的变化研究  

Study on Changes of Esophageal Acid Exposure in Chronic Superficial Gastritis Patients after Helicobacter Pylori Eradication

作　　者：项文坤[1] 熊锋宝[1] 

机构地区：[1]南昌大学第三附属医院消化一科,南昌330008

出　　处：《临床消化病杂志》2009年第4期203-205,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨慢性浅表性胃炎(CSG)患者根除幽门螺杆菌(Hp)后食管酸暴露的变化关系。方法采用24h食管pH监测的方法,定量观察Hp阳性CSG患者根除Hp组和对照组3月后食管酸暴露的变化。CSG患者60例,按就诊门诊号随机分为治疗组和对照组。治疗组均采用丽珠唯三联方案,对照组不采用药物治疗。待Hp根除后,对比研究Hp根除组和对照组所测得的24h食管pH监测参数。结果Hp根除组和对照组治疗3月后两组24h食管pH监测主要5项观察指标均无显著性差异,P>0.05。结论CSG患者根除Hp菌后食管酸暴露无明显改变,Hp可能与GERD发生无关。Objective To study on changes of esophageal acid exposure in chronic superficial gastritis patients after helicobacter pylori（Hp） eradication. Methods Consecutive symptomatic chronic superficial gastritis （CSG） patients were studied 60 patients were divided randomly into the group underwent Hp eradication therapy or the group underwent non-therapy. After eradication 24 hours esophageal pH-monitoring were underwent 3 months after the end of therapy. Results No significant differences were observed in terms of 24 hours esophageal pH-monitoring between the group underwent Hp eradication therapy and the group underwent non-therapy with CSG patients. Conclusion Eradication of Hp doess not change esophgeal acid exposure with CSG patients. Hp has no protective effect against GERD and it possibly can not accelerate the development of GERD.

关 键 词：慢性浅表性胃炎 幽门螺杆菌 24 h食管pH监测 

分 类 号：R573.3[医药卫生—消化系统]