颅颌紊乱症发病机制的比较研究  

A comparitive study on the pathogenesis of craniomandibular disorders

作　　者：王海鹰[1,2,3,4] 周继林[1,2,3,4] 洪民[1,2,3,4] 李维华[1,2,3,4] 杨梅芳[1,2,3,4] 王沛英[1,2,3,4] 王东胜[1,2,3,4] 邓斌[1,2,3,4] 郝秀华[1,2,3,4] 张曙光[1,2,3,4] 侯宁[1,2,3,4] 

机构地区：[1]解放军总医院口腔科 [2]解放军总医院病理科 [3]解放军总医院生化室 [4]解放军总医院耳研所

出　　处：《军医进修学院学报》1998年第3期167-169,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：深入研究颅颌紊乱症的发病机制及其病理特征。方法：建立过度张口和咬合创伤两组动物模型，同时观察颞颌关节（ＴＭＪ）和咀嚼肌的组织病理学改变、ＴＭＪ软组织Ｐ物质和前列腺素Ｅ２的分布及变化、咀嚼肌前列腺素Ｅ２和Ｆ２α的含量变化，比较研究两种致病方式的共性与个性。结果：（１）过度张口和咬合创伤均可导致ＴＭＪ和咀嚼肌的损伤，且均以盘周附着组织和相关的咀嚼肌反应最显著。（２）两种致病方式的损伤反应部位有所不同，过度张口组翼外肌下头和颞肌反应较强，咬合创伤组翼外肌上头和嚼肌反应显著。Objective:To study furtherly on the pathogenesis and the characteristics of craniomandibular disorders (CMD).Methods:Animal models of the overextended opening and the traumatic occlusion were established for this study. And the histopathologic observations of the temporomandibular joint (TMJ) and masticatory muscle, immunohistochemical staining of substance P (SP) and prostaglandin E2(PGE2) in TMJ soft tissue, and radioimmunologic analyses of PGE2 and PGE2α in masticatory muscle were performed and the pathogenicity of these two pathogenic patterns was compared.Results:(1)Overextended opening and traumatic occlusion resulted in some injury to TMJ and masticatory muscles. Among the injured tissues, the disc attachment and correlative masticatory muscles underwent the most obvious traumatic changes. (2)There were some differences in the injury sites depending on the particular pathogenic pattern. The lowerhead of the lateral pterygoid muscles and the temporalises showed greater changes of injury in the overextended opening groups, while the upper head of the lateral pterygoid muscles and the masseteres produced more notable changes of injury in the traumatic occlusion groups. Conclusion:The pathogenesis and the pathological characteristics of CMD can be affected by different pathogenic patterns.

关 键 词：颅颌紊乱症 颞下颌关节紊乱 发病机制 比较研究 

分 类 号：R782.630.2[医药卫生—口腔医学]