盐酸川芎嗪肺靶向微球理化性质的研究  

STUDY ON PHYSICAL AND CHEMICAL PROPERTIES OF LIGUSTRAZINE HYDROCHLORIDE MICROSPHERES

作　　者：曾凡彬[1] 陆彬[1] 杨红[1] 

机构地区：[1]华西医科大学药学院

出　　处：《中国医药工业杂志》1998年第8期354-359,共6页Chinese Journal of Pharmaceuticals

基　　金：卫生部科学基金

摘　　要：考察了盐酸川芎嗪肺靶向微球的微粉学性质、热解稳定性、载药量和体外释药模式。结果表明，微球为类白色圆球状粉末，平均算术粒径为１２．６５μｍ，５～２４．９μｍ，粒径范围的微球数占总数的８７．５％，平均堆密度为０．５９ｇ／ｍｌ，休止角为６８．６３°，临界相对湿度为５６％，热解活化能为８１．６ｋＪ／ｍｏｌ，反应级数为１。用ＵＶ法测得微球载药量为１７．０％，微球体外释药符合一级动力学规律。The micropowder property, stability to thermal decomposition, drug content and drug releasing pattern in vitro of lung targeting microspheres of ligustrazine hydrochloride were investigated. The microspheres looked like whitish spherical powder, and the arithmetic mean diameter of the microsphers was 12.65 μm, with the amount in the range from 5 to 24.9 μm being 87.5% of the total. The mean bulk density was 0.59 g/ml, and the angle of repose 68.63°. The critical relative humidity was 56%. The activation energy of thermal decomposition was 81.6 kJ/mol with the reaction order of one. The drug content in microspheres was detemined ultravioletspectrophotometrically to be 17.0%; the drug release in vitro could be described by first order kinetics. The diameter range of microspheres met the requirements of lung targeting preparations.

关 键 词：盐酸川芎嗪 肺靶向微球 微粉学性质 热解活化能 

分 类 号：R972[医药卫生—药品]