转化生长因子β_1及其受体在非酒精性脂肪肝组织中表达的临床意义  

Study of the value of the expression of transforming growth factor β_1(TGF-β_1) and its receptor(TGF-β_1R) in non-alcoholic fatty liver disease

作　　者：沈毅[1] 罗春梅[2] 

机构地区：[1]重庆医科大学附属第二医院内科,400010 [2]重庆市中医院基础部,400010

出　　处：《检验医学与临床》2009年第17期1431-1432,F0003,共3页Laboratory Medicine and Clinic

摘　　要：目的研究转化生长因子β1(TGF-β1)及其受体(PDGFR)在非酒精性脂肪肝病(NAFLD)患者肝组织中的表达、分布和意义。方法用S-P免疫组织化学方法和原位杂交检测3种NAFLD组织中TGF-β1以及TGF-β1R的表达、分布情况,并进行定量分析。结果在NAFL各种病变肝组织中,TGF-β1以及TGF-β1R的表达变化随NAFL进行性演变而呈逐渐增强趋势,表达强度与分布基本一致。主要分布于肝实质细胞及附近的汇管区、纤维间隔、炎性反应细胞浸润聚集区。肝实质细胞强于其他间质和细胞。结论TGF-β1及其受体在非酒精性脂肪性肝炎(NASH)向NASH相关肝硬化的演变过程中,其表达活性不断增强,对病变的发生和进展起着及其重要的作用,可以作为评价疾病严重程度的指标。Objective To study the expression and clinic value of transforming growth factor 61（TGF-β1） and its receptor （TGF-β1R） in non-aleoholic fatty liver disease（NAFLD）. Methods The expression of TGF-β1 and TGF- β1 R in three subgroup of NAFLD was analyzed by means of the immunohistochemistry （S-P） and in-situ hybridization. Results As the NAFLD developed, the expression of TGF-β1 and TGF-β1R were gradually increasing. The TGF-β1 and TGF-β1 R seem to appear simultaneously,which mainly distributed in hepatic cells and the region of the fibrosis and inflammation. The expression was stronger in hepatic cells than that of the other tissues or cells. Conclusion TGF-β1 and TGF-β1 R play a key role in the development of NAFLD. The TGF-β1 and TGF-β1 could be suitable to assess the severity of NAFLD.

关 键 词：非酒精性脂肪肝病 转化生长因子β1 转化生长因子Β1受体 

分 类 号：R575.5[医药卫生—消化系统]