核仁磷蛋白突变调控白血病发生机制及其临床价值  

Pathogenesis and clinical value of NPM mutations in leukemia

作　　者：邵会媛[1] 张伶[1] 

机构地区：[1]重庆医科大学医学检验系临床检验诊断学省部共建教育部重点实验室,重庆市重点实验室,重庆400016

出　　处：《生命的化学》2009年第4期481-484,共4页Chemistry of Life

基　　金：国家自然科学基金(No.30872418)资助

摘　　要：核仁磷蛋白(nucleophosmin,NPM)突变是近几年才提出的一个在急性髓系白血病中发挥重要作用的基因改变,对其分子调控机制的深入研究将有利于进一步阐述白血病的发病机制,并为白血病的临床治疗提供更多的理论依据。该文介绍核仁磷蛋白突变的特点、参与调控白血病的可能机制以及核仁磷蛋白突变指标检测的临床价值等。Nucleophosmin mutations, which have been described recently, play an important role in acute myeloid leukemia （AML）. Studying the molecular mechanisms of nucleophosmin mutations would be beneficial to elaborate the pathogenesis of AML and provide more theoretical basis for the clinical treatment of AML. In this paper, the characters and the possible regulation mechanisms of nucleophosmin mutations in AML and the clinical value of the detection of nucleophosmin mutations were reviewed.

关 键 词：核仁磷蛋白 急性髓系白血病 分子机制 

分 类 号：R733.71[医药卫生—肿瘤]