益气活血解毒法对UC模型大鼠结肠组织ICAM-1mRNA的影响  

Influence of Increasing Pneuma and Promoting Blood Flow and Deintoxication on ICAM-1mRNA in Colon Tissue of Ulcerative Colitis Rat

作　　者：安贺军[1] 王新月[2] 于玫[1] 沈静[1] 张波[3] 林芳冰[2] 

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东直门医院,北京100700 [3]解放军第306医院,北京100101

出　　处：《成都中医药大学学报》2009年第2期57-59,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(NO.30572390)

摘　　要：目的:探讨益气活血解毒法对溃疡性结肠炎(UC)模型大鼠结肠组织ICAM-1mRNA的影响。方法:用三硝基苯磺酸(TNBS)复制实验性大鼠UC模型,将其随机分为模型组、西药对照组、中药治疗组,并设正常对照组。结果:治疗10 d,西药组水平明显低于中药组(P<0.05);治疗30 d时,中药组水平下降而西药组水平升高,但两组之间相比无显著差异(P>0.05);停药10 d时,中药组水平明显低于西药组(P<0.05)。结论:以益气活血解毒立法的中药溃结复发方,与西药奥沙拉秦钠胶囊剂(畅美)比较,在缓解期可有效降低UC模型大鼠结肠组织ICAM-1mRNA表达,从而阻抑黏附分子的表达来抑制炎症反应,可能是抗溃结复发作用机制之一。Objective： To investigate influence of increasing pneuma, promoting blood flow and deintoxication on ICAM - 1 mRNA in colon tissue of ulcerative colitis model in rat. Methods： UC model of experimental rats were duplicated with TNBS and rando mLy divided into model control group, western medicine group, the traditional Chinese medicine group, and normal control group. Results： In treating 10 days, Colon organization ICAM - 1 mRNA level of rats of western medicine group was remarkblely lower than that of the traditional Chinese medicine group （ P 〈 0.05 ） . In treating 30 days, two groups havenot significantly difference （ P 〉 0. 05） . In discontinuation 10 days, the level of rats of western medicine group was remarkblely higher than that of the traditional Chinese medicine group （ P 〈 0. 05） . Conclusion ： The study shows medicinal broth of increasing pneuma, promoting blood flow and deintoxication treatment for ulcerative colitis model in rat was more cut down the level of ICAM - 1mRNA in colon tissue than treatment with western medicine. Accordingly expression of adhesion molecule is restrained, and this may be one of contra - relapse mechanism of Chinese medicine.

关 键 词：结肠炎 溃疡性 抗复发 益气活血解毒 ICAM-1MRNA 

分 类 号：R574.62[医药卫生—消化系统] R965[医药卫生—内科学]