应用纤维蛋白靶向对比剂对兔颈动脉急性和亚急性血栓的MRI分子影像学评价  

Molecular magnetic resonance imaging of acute and subacute thrombus in carotid artery with EP-2104R in rabbits

作　　者：王志红[1] 刘怀军[2] 吴文新[3] 徐英进[2] 宋利宏[2] 田泽君[4] 杨冀萍[2] 贺丹[2] 王藏海[2] 

机构地区：[1]河北医科大学第二医院神经内科,石家庄050000 [2]河北医科大学第二医院医学影像科,石家庄050000 [3]河北医科大学第二医院病理科,石家庄050000 [4]河北医科大学第二医院心脏内科,石家庄050000

出　　处：《脑与神经疾病杂志》2009年第4期257-260,共4页Journal of Brain and Nervous Diseases

基　　金：河北省自然基金资助项目(c2006000927)

摘　　要：目的评价纤维蛋白靶向结合MRI对比剂(EP-2104R)对兔颈动脉急性和亚急性血栓的显示能力,并与非对比增强和Gd-DTPA增强MRI对比。方法用颈动脉外部损伤和阻塞的方法在10只兔颈动脉内形成血栓,在血栓诱导后急性(6h)和亚急性(6d)组分别进行对比剂(EP-2104R)注入前及注入后MRI扫描,并作了组织病理学对比研究。结果纤维蛋白靶向对比剂准确的显示了所有血栓,优于非对比增强MRI和Gd-DTPA增强MRI(P<0.001)。GD-DTPA增强后不能提高发现血栓的能力。结论本研究发现纤维蛋白靶向对比剂在显示活体内急性和亚急性血栓方面优于非对比增强和Gd-DTPA增强MRI。Objective We sought to evaluate the use of a fibrin-targeted contrast agent （EP-2104R） for MR thrombus detection and compare this modality with non-contrast-enhanced（NCE） MRI and with Gd-DTPA injection at acute and subacute period after thrombus generation. Methods MR images were analyzed by 2 neuroradiologists, and contrast-to-noise ratio（CNR） in the carotid artery thrombosis were assessed. It was induced by external injury and stasis in 10 rabbits. MRI was performed before and after contrast agent injection at 6 hours group and 6 days group after injury. Correlation with histopathology was performed. Results The fibrin-targeted contrast agent accurately detected all thrombi. EP-2104R was superior to both NCE and Gd-DTPA injection （P 〈0.001 ）. Gd-DTPA injection was not associated with an improvement of thrombus detection. Conclusion We have demonstrated the superiority of a fibrin-targeted MR contrast agent for in vivo detection of acute and subacute thrombus, compared with NCE MRI and Gd-DTPA injection.

关 键 词：兔 颈动脉血栓 磁共振成像 分子影像学 EP-2104R 

分 类 号：R743.32[医药卫生—神经病学与精神病学]