急性脑梗死患者血清IL-18含量动态变化研究  

Study on the changes of serum levels of interleukin-18(IL-18) in patients with acute cerebral infarction

作　　者：左平祥[1] 高瑞利[2] 刘志和[3] 张国华[1] 张宁[1] 

机构地区：[1]河北医科大学第二医院神经内科,石家庄050000 [2]石家庄市第三医院神经内科 [3]河北医科大学第二医院放疗科,石家庄050000

出　　处：《脑与神经疾病杂志》2009年第4期271-272,共2页Journal of Brain and Nervous Diseases

基　　金：河北省科学技术研究与发展计划项目(07276101D-82);河北省卫生厅医学科学研究重点课题(07065)

摘　　要：目的动态观察急性脑梗死患者血清白介素-18(Interleukin-18,IL-18)含量变化,探讨炎症因子在脑梗死发病机制中的作用。方法选取46例急性脑梗死患者发病1d、3d、7d和14d时的空腹静脉血,采用双抗体夹心酶联免疫吸附法(ELISA)测定血清IL-18的水平,并与30名健康对照组比较。结果急性脑梗死患者发病1d内、3d、7d和14d时血清IL-18水平均显著高于正常对照组(P<0.05),其中发病3d水平最高,随时间推移及治疗的介入,炎症因子水平逐渐下降;3d测定的不同梗死体积患者血清IL-18含量存在显著性差异(P<0.05)。结论急性脑梗死患者血清IL-18水平明显升高,并与急性脑梗死的体积密切相关,对炎症反应的干预治疗可能有利于减轻缺血性脑损害。Objective To explore the role of IL-18 in the pathogenesis of acute cerebral infarction. Methods The study included 46 patients with acute cerebral infarction and 30 healthy people as control. Serum IL-18 was measured by enzyme-linked immunosorbent assay （ELISA）respectively at 1,3,7,14 days. Results Compared with control group, the serum levels of IL-18 at 1,3,7,14 days in patients with acute cerebral infarction were increased significantly （ P 〈 0. 05 ） , the level at 3rd day was the highest in patients with acute cerebral infarction. There was a positive correlation between the increasing degree of serum levels of IL-18 and the size of infarct area （ P 〈 0.05 ）. Conclusion Serum IL-18 was increased significantly in patients with acute cerebral infarction, which possibly played a key role in the pathogenesis of acute cerebral infarction, therefore anti-inflammatory drugs maybe will become potential new therapeutic agents for acute cerebral infarction.

关 键 词：急性脑梗死 白介素-18(IL-18) 酶联免疫吸附 

分 类 号：R743.32[医药卫生—神经病学与精神病学]