EMMPRIN、HER-2蛋白表达与胃癌侵袭转移的关系  

Correlation of the expression of EMMPRIN and HER-2 proteins with the invasiveness and metastasis of human gastric carcinoma

作　　者：高俊[1] 陈洪雷[1] 薛敬玲[1] 朱润庆[1] 

机构地区：[1]武汉大学基础医学院病理学教研室,湖北省武汉市430071

出　　处：《世界华人消化杂志》2009年第19期1952-1956,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨细胞外基质金属蛋白酶诱导因子(EMMPRIN)、人表皮生长因子受体2(HER-2/neu)蛋白表达与人胃癌侵袭转移的关系,以及2种蛋白表达之间的关系.方法:应用量子点免疫荧光组织化学技术检测人胃癌组织芯片150芯(包括70例胃癌组织和5例正常胃黏膜组织)中EMMPRIN和HER2的蛋白表达,并分析他们与临床病理特征的相关性.结果:胃癌和正常胃黏膜组织中的EMMPRIN阳性表达率分别为72.86%和20.00%,差异有显著性(P=0.029).在胃癌组织中HER-2蛋白的阳性率为47.14%(33/70),高于正常胃黏膜组织,但差异无显著性(P=0.063).EMMPRIN、HER-2蛋白表达与胃癌患者年龄、性别、分化程度、肿瘤的浸润深度以及临床TNM分期之间差异均无显著性(P>0.05),仅与淋巴结转移显著相关(P<0.05).在70例胃癌组织中EMMPRIN与HER-2蛋白表达之间呈显著正相关(r=0.383,P=0.001).结论:EMMPRIN与HER-2/neu可能协同促进了胃癌的淋巴结转移.AIM： To investigate the correlation of the expression of extracellular matrix metalloproteinase inducer （EMMPRIN） and human epidermal growth factor receptor 2 （HER-2/neu） with the invasiveness and metastasis of human gastric carcinomas, as well as the correlation between the expression of these two proteins in human gastric carcinoma. METHODS： The expression of EMMPRIN and HER-2 proteins was detected by quantum dotbased immunofluorescence histochemistry using 150 tissue microarrays containing 70 gastric carcinoma specimens and 5 normal gastric mucosal specimens to analyze the correlation of their expression with the clinicopathologic characteristics of gastric carcinoma. RESULTS： The positive rate of EMMPRIN protein in the gastric carcinoma was significantly higher than that in normal gastric mucosa （72.86% vs 20.00%, P =0.029）, whereas no significant difference （P=0.063） was observed in the positive rate of HER-2 protein though the rate in the gastric carcinoma （47.14%） was higher than that in normal gastric mucosa. EMMPRIN and HER-2 protein expression was not correlated with patient age and sex, the degree of differentiation, the depth of tumor invasion and clinical TNM stage （P 〉 0.05）, but significantly associated with lymph node metastasis （P 〈 0.05）. Moreover, a positive correlation was observed between the expression proteins in 70 gastric 0.383, P = 0.001）. of EMMPRIN arLd HER-2 carcinoma specimens （r = CONCLUSION： EMMPRIN and HER-2 may synergistically promote the lymph node metastasis of gastric carcinomas.

关 键 词：胃癌 细胞外基质金属蛋白酶诱导因子 人表皮生长因子受体2 组织芯片 量子点 

分 类 号：R735.2[医药卫生—肿瘤]