胃十二指肠黏膜防护研究进展  

Advance in gastroduodenal mucosal defense

作　　者：吴成跃 张传勇 

机构地区：[1]武警8690部队医院消化内科,江苏省宜兴市214206

出　　处：《世界华人消化杂志》2009年第19期1957-1961,共5页World Chinese Journal of Digestology

摘　　要：胃肠道对于药物、缺血及再灌注、Hpylori感染等内源性和外源性损伤具有多重保护机制,包括胃黏膜血流、上皮细胞屏障、碳酸氢盐分泌调节上皮细胞表面pH值等.本文就近来宿主对Hpylori感染的防御、十二指肠花生四烯酸分泌、非甾体类消炎药诱发的胃肠道损伤的保护、凋亡及治疗进行综述.The gastrointestinal tract has developed multiple mechanisms of protection from intrinsic and extrinsic injury, including but not limited to drugs, ischemic/reperfusion injuries, and infections such as Helicobacter pylori. These range from mucosal blood flow and strengthening the epithelial barrier to luminal factors such as HCO3 secretion and regulating epithelial cell-surface pH. We reviewed recent development in host defense against Helicobacter pylori, duodenal bicarbonate secretion, protection from nonsteroidal antiinflammatory drugs induced gastrointestinal injury, and apoptosis, as well as newer therapies.

关 键 词：花生四烯酸 环氧合酶抑制剂 来普汀 基质金属蛋白酶 食欲素 存活素 胃 十二指肠 

分 类 号：R57[医药卫生—消化系统]