自身抗体——肿瘤新的早期诊断标志物  

Autoantibodies:the early diagnostic biomarkers for tumors

作　　者：李官成[1] 童永清[1] 

机构地区：[1]中南大学肿瘤研究所,湖南长沙410078

出　　处：《西安交通大学学报（医学版）》2009年第4期391-394,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：肿瘤标志物是指肿瘤细胞本身存在的或分泌的、能反映肿瘤的存在和生长的特异性物质。血清肿瘤标志物已被广泛应用于肿瘤的检测,但是这些标志物的检测是基于肿瘤抗原,在肿瘤的筛选和诊断方面存在很多的不足。本文就目前基于肿瘤患者体内针对肿瘤抗原的自身抗体作为肿瘤诊断的标志物进行综述。这种检测方法是利用肿瘤抗原来检测肿瘤自身抗体,其特异性和敏感性优于传统的检测方法,并为肿瘤的筛选和诊断提供了新的手段。Tumor markers refer to the specific substances that exist in tumor cells themselves or are secreted by tumor cells. They can reflect the existence and growth of the tumor. The serum tumor biomarkers have been widely applied in tumor detection, but the detection of these markers is based on the tumor antigens, and thus has many inadequacies in tumor screening and diagnosis. In this paper, we reviewed autoantibodies as tumor biomarkers against self-antigens in vivo. This method is to examine the tumor autoantibodies by using the tumor antigens, and its specificity and sensitivity are superior to the traditional examination methods. Using autoantibodies to detect tumors would provide a new method for tumor screening and diagnosis.

关 键 词：自身抗体 肿瘤标志物 早期诊断 肿瘤抗原 

分 类 号：R730.3[医药卫生—肿瘤]