HLA-DQA1等位基因与新疆哈萨克族原发性高血压的相关性  

Relationship between alleles of HLA-DQA1 and essential hypertension in Xinjiang Kazak population

作　　者：王红英[1] 邢建新[2] 周康[3] 潘泽民[4] 陆林 马海梅[1] 张慧[6] 张妍[6] 

机构地区：[1]新疆医科大学基础医学院微生物学教研室,新疆乌鲁木齐830011 [2]石河子大学医学院免疫学教研室,新疆石河子832002 [3]石河子大学医学院第一附属医院心内科,新疆石河子832008 [4]石河子大学医学院生物化学教研室,新疆石河子832002 [5]木垒县人民医院外科,新疆木垒县831900 [6]新疆医科大学公共卫生学院预防医学2006级,新疆乌鲁木齐830054

出　　处：《西安交通大学学报（医学版）》2009年第4期402-404,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：新疆生产建设兵团医药卫生专项科技课题(No .NKB03BZSYY32SY)~~

摘　　要：目的探讨新疆哈萨克族原发性高血压与HLA-DQA1等位基因的相关性。方法应用病例-对照相关性分析方法及PCR-SSP基因分型技术对新疆哈萨克族健康个体83例和高血压病患者80例(均无血缘关系),进行了HLA-DQA1等位基因分型。结果原发性高血压患者中DQA1*0301的频率为21.591%,显著高于对照组(10.345%),χ2=4.770,P<0.05,OR=2.561。DQA1*0103的频率(19.318%)显著低于对照组(34.483%),χ2=4.404,P<0.05。OR=0.477。结论HLA-DQA1*0301可能与新疆哈萨克族原发性高血压易感相关,而HLA-DQA1*0103可能在新疆哈萨克族原发性高血压发病中有保护作用。Objective To investigate the relationship between the alleles of human leukocyte antigens （HLA） DQA1 and essential hypertension （EH） in Xinjiang Kazak population in China. Methods Alleles of HLA-DQA1 were typed by polymerase chain reaction-sequence specific primers techniques in samples of 80 EH patients and 83 healthy people in case-control study （EH patients and healthy people as controls had no consanguinity with each other）. Results The frequency of DQA1 ＊ 0301 was 21. 591%, significantly higher in the EH patients than in the controls （10.345%） （X^2 =4.770, P〈0.05）. Odds ratio （OR） was 2. 561. The frequency of DQA1 ＊ 0103 significantly decreased in the group of patients with EH in comparison to the controls （19. 318% vs. 34. 483% ） （ X^2=4.404, P〈0.05）. OR was 0.477. Conclusion HLA-DQA1 ＊ 0301 was related to the susceptibility of essential hypertension in the Xinjiang Kazak population in China. In addition, it is possible that HLA-DQA1 ＊ 0103 has a role of protecting from essential hypertension.

关 键 词：高血压病 HLA—DQA1 等位基因 新疆哈萨克族 

分 类 号：R544.1[医药卫生—心血管疾病]