Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Anfisolvent  

作　　者：金鹤阳 夏菲 江翠兰 赵亚平 何琳 

机构地区：[1]School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China [2]Analysis Center of Shanghai Jiao Tong University, Shanghai 200240, China

出　　处：《Chinese Journal of Chemical Engineering》2009年第4期672-677,共6页中国化学工程学报（英文版）

基　　金：Supported by the National High Technology Research and Development Program of China(2007AA10Z350)

摘　　要：Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate （HPMCP） to maintain its bioactivity and to avoid thermal/light degradation. Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule. The effects of several operating parameters on the yield, lutein loading, encapsulation efficiency, particle size and particle size distribution of the nanocapsule were investigated. The mean diameter of nanocapsules ranged from 163 nm to 219 nm under appropriate experimental conditions. The result of scanning electron microscope showed that the nanocapsules were nearly spherical. The highest yield reached 95.35% when the initial concentration of lutein was saturated. The highest lutein loading of 15.80% and encapsulation efficiency of 88,41% were obtained under the conditions of 11 MPa, 40℃ and CHPMCP： Clutein= 5：1. The results may promote the application of lutein in food industry.Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate(HPMCP)to maintain its bioactivity and to avoid thermal/light degradation.Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule.The effects of several operating parameters on the yield,lutein loading,encapsulation efficiency,particle size and particle size distribution of the nanocapsule were investigated.The mean diameter of nanocapsules ranged from 163nm to 219nm under appropriate experimental conditions.The result of scanning electron microscope showed that the nanocapsules were nearly spherical.The highest yield reached 95.35% when the initial concentration of lutein was saturated.The highest lutein loading of 15.80% and encapsulation efficiency of 88.41% were obtained under the conditions of 11MPa,40℃ and CHPMCP︰Clutein=5︰l.The results may promote the application of lutein in food industry.

关 键 词：NANOCAPSULE LUTEIN hydroxypropylmethyl cellulose phthalate supercritical antisolvent precipitation 

分 类 号：TQ460.4[化学工程—制药化工] TQ414.1