阿立哌唑对首发精神分裂症患者代谢的影响  

Influences on serum prolactin,blood glucose and body weight for patients with first-episode schizophrenia treated with aripiprazole

作　　者：刘朝军[1] 田素英[1] 张传芝[1] 卢世臣[1] 韩鹏[1] 

机构地区：[1]山东济宁市精神病防治院,272051

出　　处：《临床精神医学杂志》2009年第4期244-246,共3页Journal of Clinical Psychiatry

基　　金：济宁市科技局计划内项目(编号:2005-26)

摘　　要：目的:探讨阿立哌唑对精神分裂症患者泌乳素、血糖和体质量的影响。方法:用随机方法将100例精神分裂症患者分成阿立哌唑组、利培酮组和氯氮平组,治疗12周。于治疗前和治疗4、8、12周,采用放射免疫法测量泌乳素、血糖和体质量。结果:治疗前后泌乳素、血糖水平和体质量,阿立哌唑组无明显变化,利培酮组和氯氮平组治疗后显著增加,并且与阿立哌唑组比较差异具有显著统计学意义(P<0.05或P<0.01)。结论:阿立哌唑对精神分裂症患者的泌乳素、血糖和体质量影响较小。Objective： To explore the influences on serum prolactin, blood glucose and body weight for patients with first-episode schizophrenia treated with aripiprazole. Method： 100 patients with first-episode schizophrenia were randomly divided into aripiprazole group,risperidone group and clozapine group for 12 weeks treatment. The serum prolactin, blood glucose and body weight were measured before and after 4,8 and 12 weeks treatment. Results：There were no significant changes in the level of serum prolactin, blood glucose and body weight for patients in aripiprazole group after 12 weeks treatment, however, all index above statistically increased in patients of risperidone group and clozapine group compared with those in aripiprazole group （P 〈0.05 or P 〈 0.01 ）. Conclusion：Aripiprazole may have less effect on serum prolactin, blood glucose and body weight for patients with schizophrenia.

关 键 词：精神分裂症 阿立哌唑 泌乳素 血糖 体质量 

分 类 号：R749.3[医药卫生—神经病学与精神病学]