利培酮引起高催乳素血症的预防  

A study on the prevention of risperidone-induced hyperprolactinemia

作　　者：李颖[1] 高靖捷[1] 

机构地区：[1]上海市奉贤区精神卫生中心,201418

出　　处：《临床精神医学杂志》2009年第4期252-253,共2页Journal of Clinical Psychiatry

摘　　要：目的:研究维生素B6预防抗精神病药所致高催乳素血症的效果。方法:在服用抗精神病药同时预防性应用维生素B612周,以阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)评定,并则定血清催乳素值,与对照组进行比较。结果:治疗4周预防组血清催乳素值显著低于对照组,生殖系统不良反应明显少于对照组。治疗8、12周时两组差异有统计学意义(P<0.01)。结论:早期应用维生素B6可有效预防药源性高催乳素血症的发生。Objective ：To explore the preventive effect of vitamin B6 on antipsychotic drug-induced hyperprolactinemia. Method： Preventive use of vitamin B6 persisted through 12 weeks of antipsychotic treatment. Symptoms and side effects were evaluated with positive and negative symptom scale （ PANSS ） and treatment emergent symptom scale（TESS）. Prolactine levels were tested and compared with those in control group. Results：Serum prolactine level and rate of side effects in reproductive system decreased in research group after 4 weeks and showed significant difference between the two groups. Conclusion ： Early use of vitamin B6 may effectively decrease the occurrence of antipsychotic drug-induced hyperprolactinemia.

关 键 词：精神分裂症 高催乳素血症 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]