星状神经节阻滞对乳腺癌围手术期体液免疫的影响  

The effect of stellate ganglion block on humoral immunity at perioperative period in patients with breast cancer.

作　　者：蔡海峰[1] 王玉虎 赵刚[1] 王钧[1] 

机构地区：[1]华北煤炭医学院附属人民医院普瘤科,唐山063001 [2]河北武警总队医院唐山分院

出　　处：《中国综合临床》2009年第9期985-987,共3页Clinical Medicine of China

摘　　要：目的观察星状神经节阻滞（SGB）对乳腺癌患者围手术期体液免疫的影响。方法选择乳腺癌改良根治术女性患者80例，随机分为对照组40例，干预组40例。观察采用星状神经节阻滞干预前（T1）、干预后（T2）和术毕30min（T3）时IgG、IgA、IgM的变化并与对照组进行对比。结果与T1比较，T2、T3时间点2组IgG、IgA、IgN均有不同程度下降（P〈0．05，P〈0．01）。干预组与对照组比较T3时间点IgG[（11．8±2．2）g／L与（9．5±1．5）g／L，t=5．4630，P=0．0041]、IgA[（1．9±0．3）g／L与（1．7±0．4）g／L，t=2．5298，P=0．0134]差异均有统计学意义；干预组与对照组比较T2时间点IgM[（2．5±0．8）g／L与（2．1±0．6）g／L，t=2．8276，P=0．0072]、T3[（2．1±0．5）g／L与（1．6±0．5）g/L，t=4．4721，P=0．0000]差异均有统计学意义。结论术前星状神经节阻滞可减轻乳腺癌改良根治术患者体液免疫的抑制程度。Objective To observe the effects of stellate ganglion block （SGB） on humoral immunity function in patients who received modified radical mastectory （MRM）. Methods Eigty female patients were randomly divided into control group（ group Ⅰ ,n =40） and intervention group （group Ⅱ , n = 40）. Blood samples were taken pre-intervention （T1）, after intervention （T2 ） and 30 min after operation（ T3 ） for the determination of IgG, IgA, IgM. Results Compared with T1, IgG, IgA, IgM at T2 and T3 in two groups were lowered. IgG [ （ 11.8 ± 2.2 ） g/L vs （9.5 ± 1.5）g/L,t =5. 4630,P =0. 0041 ] and IgA [（1.9 ±0.3）g/L vs （1.7 ±0.4）g/L,t =2.5298,P = 0.0134 ] at T3 in group Ⅱ were significantly different as compared with that of group I ; IgM at T2 [ （2.5 ± 0.8 ） g/L vs （2.1 ±0.6） g/L,t =2. 8276,P =0.0072] and T3 [ （2.1 ±0.5）g/L vs （ 1.6 ±0.5）g/L,t =4.4721 ,P = 0.0000 ] was significantly different between the two groups. Conclusions Preoperative-SGB can improve the inhibition degree of humoral immunity caused by modified radical mastectory.

关 键 词：星状神经节阻滞 乳腺癌 体液免疫 围术期 

分 类 号：R737.9[医药卫生—肿瘤]