气温骤降条件下炎性细胞因子、基因表达与卒中发病的关系  

Relationship between inflammatory factors, gene and stroke onset under the conditions of the sudden drop of temperature

作　　者：席秋江[1] 吴裕臣[1] 徐仁佃[1] 

机构地区：[1]南昌大学第一附属医院神经内科,330006

出　　处：《国际脑血管病杂志》2009年第7期514-517,共4页International Journal of Cerebrovascular Diseases

基　　金：国家科技支撑计划课题（2008BA168B01）

摘　　要：除受传统危险因素影响之外，卒中发病还与气温骤降有关。对绝大多数地区的研究发现，卒中与冷天气关系密切，后者通过多种机制影响卒中的发病，如血管调节机制的季节变化、血液成分的改变以及对感染因素的影响等。研究证实，炎症因子在动脉粥样硬化和卒中发病中起着重要作用，而寒冷应激对卒中患者基因表达产生的影响也可能起着重要作用。文章概述了气温骤降与卒中发病的关系和机制。In addition to the influence of traditional risk factors, stroke onset is associated with the inducement of the sudden drop of temperature. The studies of the vast majority of areas have found that stroke is closely related to cold weather, The latter impacts the onset of stroke through a variety of mechanisms, such as the seasonal changes of vascular regulatory mechanism, changes in blood compositions, and the impact on infection factors. Studies have confirmed that inflammatory factors play an important role in atherosclerosis and stroke onset, while the cold stress may also play an important role on the differences of gene expression in patients with stroke, This paper summarizes the relationship and mechanisms between the sudden drop of temperature and stroke onset.

关 键 词：天气 炎症介导素类 细胞因子类 基因表达 卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]