人乳头瘤病毒检测在宫颈癌前病变筛查中的应用  

HPV DETECTION APPLICATION IN CERVIX CANCER PRECANCEROUS CHANGE SCREENING

作　　者：邓海萍[1] 莫可良[1] 秦梅[1] 曾定元[1] 

机构地区：[1]广西医科大学第四附属医院柳州市工人医院,柳州565005

出　　处：《现代预防医学》2009年第16期3110-3111,共2页Modern Preventive Medicine

摘　　要：[目的]探讨人乳头瘤病毒(HPV)检测在宫颈癌前病变筛查中的应用价值。[方法]对2006年7月～2007年7月在我院就诊的147例患者行薄层液基细胞学检查,人乳头瘤病毒检测及阴道镜检查。[结果]147例患者中HPV感染阳性例数为65例,占44.2%,平均年龄为36.6岁;阴性例数为82例,占55.8%,平均年龄为36.3岁。慢性宫颈炎94例,HPV感染阳性例数为25例,占26.6%;CINⅠ级24例,HPV感染阳性例数为16例,占66.7%;CINⅡ级14例,HPV感染阳性例数为10例,占71.4%;CINⅢ级8例,HPV感染阳性例数为7例,占87.5%;宫颈癌7例,HPV感染阳性例数为7例,占100%。高危型HPV感染阳性率随宫颈病变程度加重而明显升高。[结论]在宫颈癌前病变筛查中,人乳头瘤病毒检测有重要的临床价值。[Objective] To investigate the value of HPV in screening on precancerous lesions of uterine cervix. [Methods] Lamellar liquid based cytology examination,HPV detection and colposcopy vaginoscopy were performed to detect 147 patients in hospital from June 2007 to July 2007. [Results] Among 147 patients,65 patients were detected to be positive HPV infection,accounted for 44.2%,and the average mean age was 36.6 years old. 82 patients detected to be negative HPV,accounted for 55.8%,and the mean age was 36.3 years old. 94 cases were detected to be chronic cervicitis,and 25 cases were detected to be positive HPV infection,accounted for 26.6%;24 cases were CIN,and 16 cases were positive HPV infection accounted for 66.7%;14 cases were CINⅡ,and 10 cases were detected to be positive HPV infection accounted for 71.4%;8 cases were CIN Ⅲ,and 7 cases were positive HPV infection accounted for 87.5%;7 cases were uterine cervix cancer,and 7 cases were detected to be positive HPV infection accounted for 100%. Positive rate of high risk HPV infection increased with the aggravation of cervix uter pathological changes. [Conclusion] The HPV detection has great clinical value in screening for precancerous lesions of uterine cervix.

关 键 词：人乳头瘤病毒 宫颈癌前病变 筛查 

分 类 号：R737.33[医药卫生—肿瘤]