基底细胞样乳腺癌临床病理研究  

A Clinicopathological study of basal-like breast carcinoma

作　　者：王海[1] 冷冬妮[2] 石群立[1] 周航波[1] 姜少军[1] 杜军[1] 周晓军[1] 

机构地区：[1]南京军区南京总医院病理科,江苏南京210002 [2]解放军第454医院病理科,江苏南京210002

出　　处：《东南国防医药》2009年第4期293-297,共5页Military Medical Journal of Southeast China

基　　金：南京军区南京总医院青年基金(Q2008065)

摘　　要：目的 研究基底细胞样乳腺癌的临床病理特点，并分析其免疫组化及超微结构特征。方法采用HE、免疫组化（EnVision法）及电镜技术观察12例基底细胞样乳腺癌。结果12例患者均为女性，年龄35—73岁，中位年龄54岁。肿瘤直径2．4～3cm，无包膜。组织学上肿瘤组织具有推进式的边缘，周围伴淋巴细胞浸润。瘤细胞呈合体细胞样，通常见坏死。所有病例显示为高级别癌，核分裂象易见。4例发生淋巴结转移。免疫组化：ER、PR和HER2均阴性，CK5／612例阳性，CK14阳性9例，EGFR阳性10例。电镜示肿瘤细胞有异型性，胞质内可见张力原纤维丝。结论基底细胞样型乳腺癌具有独特的组织学与免疫表型特征，EGFR蛋白常过度表达，对于EGFR分子靶向治疗可能有效。Objective To study the clinicopathological features of basal-like breast carcinoma and to analyze their immunohistochemical and uhrastructural features. Methods 12 cases of basal-like breast carcinoma were investigated with HE staining, EnVision immunostaining and electron microscopy. Results All patients were females, 35 -73 years in age （median 54 years）. The tumors were 2.4 - 3 cm in diameter, none encapsulated. Histologically, tumors had pushing margins with a peri -tumoural lymphocytic infiltrate and had a syncytial growth pattern. They often showed areas of necrosis . All cases were high grade with a very high mitotic index. 4 cases had nodal metastases. Immunohistochemically , the tumors were negative for ER,PR and HER2, whereas positive for CK5/6 （12 cases）, CK14 （9 cases） and EGFR （10 cases）. U1- trastrueture showed the cells of tumors were heteromorphism, tonofibril in intracytoplasm. Conclusion Basal- like breast carcinoma has unique histological and immunohistochemical features. The EGFR protein is often overexpressed in this subtype, so patients might benefit from treatment with anti -EGFR drugs.

关 键 词：乳腺 基底细胞样癌 免疫组化 超微结构 

分 类 号：R730.267.1[医药卫生—肿瘤]