BAG-1、VEGF在大肠癌中的表达及意义  

EXPRESSION AND SIGNIFICANCE OF BAG-1 AND VEGF IN COLONRECTAL CARCINOMA

作　　者：王慧[1] 陈龙[1] 刘绍晨[1] 梅立新[1] 宫凤春[1] 郑纪宁[1] 

机构地区：[1]承德医学院,河北承德067000

出　　处：《承德医学院学报》2009年第3期243-246,F0002,共5页Journal of Chengde Medical University

摘　　要：目的:探讨抗凋亡基因BAG-1、血管内皮生长因子(VEGF)在大肠癌发生、发展中的作用及二者的相关性。方法:用免疫组织化学SABC法分别检测12例正常大肠粘膜、40例大肠癌组织BAG-1和VEGF蛋白的表达情况。结果:BAG-1和VEGF在大肠癌中的表达均明显高于正常粘膜(P<0.05,P<0.01)。BAG-1在大肠癌中的表达与分化程度、淋巴结转移及Duke’s分期有关(P<0.01),与浸润深度无关(P>0.05);VEGF在大肠癌中的表达与分化程度、淋巴结转移、Duke’s分期及浸润深度均有关(P<0.01)。大肠癌中BAG-1的表达与VEGF有明显相关性(P<0.01)。结论:BAG-1和VEGF参与了大肠癌的发生发展过程,可作为判断大肠癌生物学行为的参考指标。Objective：To investigate the expressions of BAG-1 and VEGF in development of colorectal carcinoma and determine their relationships.Methods：SABC immunohistochemical staining was used to observe the expression of BAG-1 and VEGF protein in 12 normal colonrectal mucosa and 40 colonrectal carcinoma specimens.Results： The expression of BAG-1 and VEGF protein in colonrectal carcinoma were obviously higher than normal colonrectal mucosa （P〈0.05, P〈0.01）. In colorectal carcinoma, the BAG-1 expression was related to differentiation degree, lymph node metastasis and Duke＇s stage （P〈0.01）; the VEGF expression was related to differentiation degree, lymph node metastasis, Duke＇s stage and depth of infiltration （P〈0.01）. The expression of BAG-1 in colorectal carcinoma had obvious correlation with VEGF expression（P 〈 0.01）.Conclusions：BAG-1 and VEGF may play an important role in development of conlonrectal carcinoma and can be acted as indicators for judging biological behaviour of colontectal carcinoma.

关 键 词：BAG—1 VEGF 大肠癌 免疫组织化学染色 

分 类 号：R735.3[医药卫生—肿瘤]