急性脑梗死患者血清神经元特异性烯醇酶的动态变化分析及预后评估  

Prognosis and dynamic changes analysis of serum neuron-specific enolase of patients with acute cerebral infarction

作　　者：唐勇[1] 李和莅[1] 

机构地区：[1]成都市第二人民医院急诊科,四川成都610017

出　　处：《实用医院临床杂志》2009年第5期70-72,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨血清神经元特异性烯醇酶(NSE)动态变化规律及其对急性脑梗死患者病情、预后的评估。方法采用酶联免疫测定法检测76例急性脑梗死患者发病后血清NSE水平,并观察其动态变化情况;选择同期40例健康人作为对照。结果起病第1、3天NSE浓度较正常对照组[(7.58±1.40)μg/L]显著升高(P<0.05);发病3、7、14天各时间点预后不良脑梗死患者NSE水平均明显高于预后良好者,差异均有显著性意义(P<0.05);不同病情程度急性脑梗死患者血浆NSE水平存在显著性差异(P<0.05)。结论监测血清NSE水平可能有助于预测脑梗死的病情变化和预后情况,临床医生应予以重视。Obiective To explore dynamic changes of the Serum neuron-specific enolase in patients with acute cerebral infarction, and to assess and analysis the prognosis. Methods Seventy-six patients between May 2001 and February 2009 in our Hospital were measured with after onset of serum neuron-specific enolase （ NSE ） levels by enzyme-linked immunosorbent assay （ELISA） , and to observe the dynamic changes. And the same time to select 40 cases of normal healthy people as control. Results The first 1,3 days of onset NSE concentrations than normal control group[7. 58 ± 1.40（μg/L） ] was significantly higher （ P 〈 0. 05 ）. Group of patients with poor prognosis in the incidence of 3 days levels of NSE, the first 7,14 days at different time points were significantly higher than those in patients with good prognosis group of plasma NSE levels in the same period. Clinical conditions by various types of sub-degree （light, medium and heavy） NSE compared by analysis of variance between each group, there was a significant difference （ P 〈 0. 05 ）. Conclusions To monitor dynamic changes of NSE serum levels may help to predict changes in cerebral infarction and prognosis of the disease situation. It is worthy of great importance to clinicians.

关 键 词：急性脑梗死 神经元特异性烯醇化酶 动态 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]