超声造影评价肝纤维化  

Evaluation of liver fibrosis with contrast enhanced sonography

作　　者：解丽梅[1] 郭启勇[2] 刘鑫[2] 

机构地区：[1]中国医科大学附属盛京医院超声科,辽宁沈阳110004 [2]中国医科大学附属盛京医院放射科,辽宁沈阳110004

出　　处：《中国医学影像技术》2009年第8期1447-1449,共3页Chinese Journal of Medical Imaging Technology

基　　金：辽宁省教育厅高等学校科研项目计划(2008742)

摘　　要：目的评估应用超声造影评价肝纤维化的临床价值。方法对慢性病毒性肝炎患者32例及健康对照组6名在反相脉冲谐波模式下,经肘静脉注射超声造影剂SonoVue,记录造影剂到达肝动脉时间(HAAT)、到达门静脉时间(PVAT)及到达肝静脉时间(HVAT),计算造影剂到达肝动脉与到达肝静脉间隔时间(VAT)和到达门静脉与到达肝静脉间隔时间(VVT)。结果HVAT、VAT、VVT与肝纤维化程度呈负相关,中度及重度肝纤维化组HVAT、VAT、VVT缩短。以肝纤维化达到S4期为阳性判断标准,HVAT、VAT、VVT的ROC曲线下面积为0.83～0.84。结论超声造影对重度肝纤维化的诊断具有一定临床价值,但在诊断轻度肝纤维化的准确性方面存在欠缺。Objective To observe clinical value of evaluating liver fibrosis with contrast enhanced ultrasonography. Methods The study included 32 patients with chronic virus hepatitis and 6 healthy controls. Under the mode of pulse-inversion harmonic imaging, bolus of ultrasound contrast agent was injected through cubital vein, and then hepatic artery arrival time （HAAT）, portal vein arrival time （PVAT）, and hepatic vein arrival time （HVAT） were recorded. The interval time between hepatic artery arrival time and hepatic vein arrival time （VAT） and the interval time between portal vein arrival time and hepatic vein arrival time （VVT） were calculated. Results HVAT, VAT and VVT were negatively correlated with the severity of liver fibrosis. Areas under ROC curve of HVAT, VAT, VVT were 0. 83-0.84 when S4 liver fibrosis was taken as positive. Conclusion Contrast enhanced ultrasonography is of certain value for the diagnosis of severe liver fibrosis, but the accuracy for mild liver fibrosis is somehow limited.

关 键 词：肝纤维化 肝硬化 超声检查 造影剂 

分 类 号：R575.1[医药卫生—消化系统] R445.1[医药卫生—内科学]