脂肪因子与非酒精性脂肪性肝病研究进展  

Progresses about Adipokines and Nonalcoholic Fatty Liver Disease

作　　者：鲍丽静[1] 向晓星[1] 

机构地区：[1]江苏省苏北人民医院扬州大学临床医学院消化科

出　　处：《医学综述》2009年第16期2420-2422,共3页Medical Recapitulate

摘　　要：非酒精性脂肪性肝病的发病机制目前尚不十分清楚，胰岛素抵抗可能是其发病的关键环节。与胰岛素抵抗相关的脂肪因子，包括瘦素、脂联素、抵抗素、肿瘤坏死因子、内脏脂肪素等，在非酒精性脂肪性肝病的形成、炎症改变和纤维化过程中发挥着重要作用。脂肪因子在非酒精性脂肪性肝病中的作用机制仍不甚明确，其相互关系也有待进一步研究。The pathophysiology of nonalcoholic fatty liver disease （NAFLD） is not well under-stood. Insulin resistance might play an important role in the progress of NAFLD. The adipokines including leptin, adiponectin, resistin, tumor necrosis factor and visfatin are closely associated with the development of hepatic inflammation and fibrosis in patients with NAFLD. The mechanisms of the role of adipokines in NAFLD are unclear and their mutual relationships needs further studying.

关 键 词：脂肪因子 非酒精性脂肪性肝病 胰岛素抵抗 

分 类 号：R575[医药卫生—消化系统]