人端粒酶催化亚基肿瘤相关性研究  

Study about Human telomerase catalytic subunit related to Tumor

作　　者：贾振华[1] 唐红伟[1] 彭智[1] 梁杰[1] 

机构地区：[1]广东医学院附属医院整形外科

出　　处：《医学综述》2009年第16期2428-2431,共4页Medical Recapitulate

摘　　要：人端粒酶催化亚基（hTERT）基因转录的从头激活是端粒酶活化的主要限速步骤，受到多种癌基因或抑癌基因产物的精密调控。构建hTERT启动子调控抗肿瘤基因的逆转录病毒载体，使抗肿瘤基因在端粒酶阳性的肿瘤细胞内定向表达，有望用于肿瘤基因治疗。The denovo transcription of hTERT gene represents a major rate-limiting step in the activation of human telomera.se. The expression of hTERT is strictly regulated by several oneogene products and tumor suppressor gene products in normal cells. The construction of a reverse-transcriptional virus vector that contains the promoter of hTERT without losing its specificity can dramatically augment the expressions of anticancer genes in telomerase-positive cancer cells, which prompts the use of an hTERT promoter for anticancer gene therapies.

关 键 词：端粒酶 人端粒酶催化亚基 肿瘤 基因治疗 

分 类 号：R730.54[医药卫生—肿瘤]