阿尔茨海默病的药物治疗研究进展  

Current Status and Trends of Drugs for Alzheimer′s Disease

作　　者：陈泽峰[1] 

机构地区：[1]天津市第四中心医院神经科

出　　处：《医学综述》2009年第16期2449-2452,共4页Medical Recapitulate

摘　　要：阿尔茨海默病是一种以进行性认知功能减退为主要临床症状的慢性中枢神经系统退行性疾病，发病机制目前仍未完全阐明。阿尔茨海默病的治疗包括抗氧化剂、抗炎药物、激素替代疗法、神经保护疗法、胆碱酯酶抑制剂、抗淀粉样蛋白的治疗和精神药理学药物等。本文主要阐述阿尔茨海默病药物治疗，尤其是胆碱酯酶抑制剂的研究进展。Alzheimer＇s disease （AD）is a chronic neurodegenerative disorder with clinical symptoms characterized by progressive cognitive decrease, the pathogenesis of which has not been elucidated. The strategies for treatment of AD included antioxidant, anti-inflammatory drugs, hormone replacement therapy, neuroprotective drugs, cholinesterase inhibitors, anti-amyloid, psychopharmacological agents and etc. This paper mainly focused on the advances the field of multi-target-directed drug development both home and abroad, especially those studies on cholinesterase inhibitors.

关 键 词：阿尔茨海默病 多靶向治疗 胆碱酯酶抑制剂 

分 类 号：R749.13[医药卫生—神经病学与精神病学]