免疫增强型肠内营养在进展期胃癌术后辅助化疗中的临床观察  

Application of Immune-Enhancing Enteral Nutrition during Postoperative Adjuvant Chemotherapy of Advanced Gastric Cancer

作　　者：伍锦浩[1] 朱达坚[1] 戎祯祥[1] 陈小伍[1] 剧永乐[1] 

机构地区：[1]南方医科大学附属顺德第一人民医院胃肠胰疝外科,广东省佛山市528300

出　　处：《岭南现代临床外科》2009年第4期279-281,共3页Lingnan Modern Clinics in Surgery

摘　　要：目的研究在进展期胃癌术后辅助化疗中应用免疫增强型肠内营养的临床疗效。方法回顾性分析本院2005年1月至2007年12月84例进展期胃癌术后辅助化疗患者的临床资料,所有患者均于术中放置空肠穿刺造口管,并延期留置空肠造口管至化疗6个疗程结束,根据术后辅助化疗期间应用不同肠内营养剂型将患者分成A、B两组,每组42例,其中A组为每个化疗疗程经空肠造口管给予免疫增强型肠内营养液(瑞能),每天1500ml,共7天,B组为每个化疗疗程经空肠穿刺造口管给予普通匀浆膳食,每天1500ml,共7天;比较两组患者化疗后营养、免疫指标。结果化疗后A组血红蛋白、血清白蛋白、前白蛋白及IL-2、NK细胞活性、CD3+、CD4+、CD4+/CD8+水平显著高于B组(P<0.05)。结论进展期胃癌在术后辅助化疗期间应用免疫增强型肠内营养可以减少化疗药物对患者营养及免疫状况的影响。[Abstract] Objective To study the chnical effects of immune-enhancing enteral nutrition during postoperative adjuvant chemotherapy of advanced gastric cancer. Methods eighty-four patients with advanced gastric cancer underwent radical gastrectomy were divided into group A （n=42） and group B （n=42）. All of the patients had been placed needle catheter jejunostomy（NCJ）feeding tube intraoperation. And all of the patients received postoperative adjuvant chemotherapy for 6 cycles and kept the NCJ feeding tube until the end of 6 periods of chemotherapy. Group A received immune- enhancing enteral nutrition Supporton through the tube 1500 ml per day, for 7 days every period, and group B received general homogeneous diet through the tube 1500 ml per day, for 7 days every period. A series of parameters including hemoglobin （Hb）, albumin （Alb）, prealbumin （PA）, transferrin （TF）, serum level of IL-2, NK cells activities, T-cell subtypes, avoirdupois were measured pre-chemotherapy and post-chemotherapy. Results In post-chemotherapy, the level of Hb, Alb, PA, IL-2, NK cells activities and T-cell subtypes of A group were significantly higher than those of B group （P〈0.05）. Conclusions Apphcation of immune-enhancing enteral nutrition during postoperative adjuvant chemotherapy of advanced gastric cancer can improve the nutrition status and immune function in the given patients.

关 键 词：胃肿瘤 辅助化疗 空肠穿刺置管 肠内营养 

分 类 号：R735.2[医药卫生—肿瘤]