pH值/温度双重敏感淀粉水凝胶的合成与表征  

Synthesis and Characterization of pH and Temperature Sensitive Starch Hydrogels

作　　者：刘美华[1] 郑敦胜[1] 杜伏玲[1] 范仁锋[1] 

机构地区：[1]广东药学院药科学院,广东广州510006

出　　处：《化工时刊》2009年第8期12-15,共4页Chemical Industry Times

基　　金：广东药学院科学研究基金(2005YKX03)

摘　　要：首先合成具有功能性基团的淀粉马来酸酯(starch-MAH),然后将starch-MAH与N-异丙基丙烯酰胺(NI-PA)共聚,合成出一种新型的淀粉水凝胶(starch-MAH/NIPA)。采用红外光谱仪(FT-IR)、扫描电镜(SEM)、差示扫描量热仪(DSC)、溶胀度测定以及体外药物释放试验,对水凝胶的结构和性能进行了表征。实验结果表明,该水凝胶具有良好的pH值、温度敏感性以及药物释放性能。The starch maleic anhydride （starch -MAH） containing vinyl and carboxyl functional groups was synthesized by the reaction of starch and maleic anhydride. Through copolymerization of starch - MAH with N - isopropylaerylamide （NIPA）, a novel starch hydrogel （starch -MAH/NIPA） was prepared. The structure and properties of the hydrogels were studied by FT - IR, SEM, DSC, swelling ratio and drug delivery experiment. The results showed that the hydrogels had good pH and temperature sensitive and drug release properties.

关 键 词：pH值/温度敏感 淀粉 水凝胶 药物释放 

分 类 号：TQ427[化学工程]