直肠癌组织中COX-2表达及与微血管和微淋巴管密度的关系  

Correlation Between COX-2 Expression and Microvascular and Microlymphatic Density in Rectal Carcinoma

作　　者：郭国湖[1] 黄惠玉[1] 李震[1] 蔡高扬[1] 陈维荣[1] 

机构地区：[1]汕头大学医学院第二附属医院心普外科,广东汕头515041

出　　处：《医学临床研究》2009年第8期1368-1371,共4页Journal of Clinical Research

摘　　要：【目的】研究直肠癌组织中COX-2表达与微血管密度（MVD）和微淋巴管密度（MLD）的关系，同时探讨COX-2表达的临床病理学意义。【方法】采用免疫组织化学方法检测95例直肠癌中COX-2的表达，同时标记CD34和D2—40用以分别检测直肠癌组织中MVD和MLD。【结果】95例直肠癌中COX-2阳性表达率为95．79％（91／95），高表达率为71．58％（68／95），COX-2的表达与患者性别、年龄、肿瘤部位等临床病理参数无关（P〉0．05）；与肿瘤大小、组织学分级、淋巴结转移、临床分期等临床病理参数有关（P〈0．05）；CCX-2高表达组的MVD和MLD值明显高于COX-2低表达及阴性组（P〈0．01和P〈0．05）。【结论】COX-2在直肠癌病人的广泛表达对肿瘤微血管及微淋巴管形成可能起重要作用。[Objective]To investigate the expression of cyclooxygenase-2（COX-2） in rectal carcinoma and its correlations with microvascular density（MVD） and microlymphatic density（MLD）. [Methods]The expression of COX-2, MVD and MLD were detected by immunohistochemistrieal method in 95 cases of rectal carei noma. [Results]In the rectal carcinoma, the positive rate of COX-2 was 95.79% and the highest expression rate of COX 2 was 71.58%. The overexpression of COX-2 was not related with the age.of patients, gender and the position of the tumor （ P〉0.05）, but related with the clinicopathologic parameters, such as tumor size and lymphatic metastasis, etc（ P 〈0. 05）. The MVD and MLD of cases with high COX-2 expression groups were significantly higher than those of cases with low and negative COX-2 expression groups （ P 〈0. 01 and P 〈0.05）. [Conclusion] The overexpression of COX 2 in rectal carcinoma patients may play an important role in tumor neovascularization and lymphatic vessel production.

关 键 词：直肠肿瘤/病理学 前列腺素内过氧化物合酶/分析 毛细血管 

分 类 号：R735.35[医药卫生—肿瘤]