乏氧组织显像剂单光子计算机断层扫描检测脑出血灶周围乏氧组织的初步研究  

Preliminary study on detection of hypoxic brain tissue around the focus of cerebral hemorrhage using HL-91 single photon emission computerized tomography

作　　者：陈润青[1] 杨友松[2] 张鹏[1] 

机构地区：[1]烟台经济技术开发区医院神经内科,264006 [2]四川省人民医院神经内科

出　　处：《临床神经病学杂志》2009年第4期297-299,共3页Journal of Clinical Neurology

摘　　要：目的探讨乏氧组织显像剂(99Tcm-HL-91)单光子计算机断层扫描(SPECT)检测脑出血灶周围乏氧组织的应用价值。方法应用HL-91SPECT脑显像对26例脑出血患者进行检测,并与CT影像学结果及5名健康对照者进行比较。结果26例脑出血患者中17例(65.38%)乏氧显像阳性,乏氧显像阳性区与CT上脑出血灶密切相关;9例阴性者中,6例为小量脑出血患者,包括2例出血量<10ml的小脑出血和丘脑出血,4例出血量<15ml的基底节区和脑叶出血者,另3例为起病后20d检查者。对照组全部阴性。结论HL-91SPECT脑乏氧显像完全适用于脑出血后乏氧组织的临床观察。HL-91SPECT检测所显示出的乏氧区与CT上的脑出血灶的密切相关。Objective To investigate the applied value of ^99Tc^m-HL-91 single photon emission computerized tomography（SPECT） in detecting the hypoxie brain tissue around the focus of cerebral hemorrhage. Methods 26 patients with cerebral hemorrhage were examined by HL-91 SPECT. And the results were compared with their skull CT imagings and other 5 healthy controls. Results 17 case （65.38%） of cerebral hemorrhage group were found hypoxie imaging positive, and the hypoxic zone was closely related to the focus of cerebral hemorrhage in CT imaging. 9 eases of cerebral hemmorhage group were found hypoxic imaging negative, 6 cases of which were small quantity cerebral hemorrhage, including 2 cases 〈 10 ml hemorrhage in cerebellar and thalamic, and 4 cases 〈 15 ml hemorrhage in basal ganglia and cerebral lobe ; another 3 negative cases were inspected at 20 d after onset. 5 cases of normal control group were all negative in HL-91 SPECT. Conclusions HL-91 SPECT hypoxic imaging is applicable to the clinical observation of hypoxie brain tissue around cerebral hemorrhage. The hypoxic zone in HL-91 SPECT imaging is closely related to the focus of cerebral hemon-hage in CT imaging.

关 键 词：脑出血 乏氧显像 单光子计算机断层扫描 

分 类 号：R743.34[医药卫生—神经病学与精神病学]