Epi—LASIK术后Haze形成的临床观察  

Clinical observation of Haze after epipolis laser in situ keratomileusis

作　　者：张亚丽[1] 左天南[1] 刘蕾[1] 胡明[1] 李招娜[1] 

机构地区：[1]济南市第二人民医院(济南眼科医院),250001

出　　处：《中国实用眼科杂志》2009年第8期835-837,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的探讨机械法准分子激光角膜上皮瓣下磨镶术（Epipolis laser in situ keratomileusis Epi—LASIK）后角膜上皮下雾状混浊（Haze）的发生情况及影响因素。方法病例选择2007年12月至2008年2月行EPi—LASIK手术治疗并定期随诊6月以上的近视患者共250例491只眼，其中男120例236只眼，女130例255只眼。年龄17～45岁（22．25±4．63）岁。观察其术后是否发生Haze，以及Haze的密度、形成及消失的时间，并对其进行比较。结果Epi—LASIK术后Haze发生率为33．60％，其中0．5级Haze31．98％，1级Haze1．63％，无1级以上Haze，平均Haze出现时间（42．75±23．50）（15—150）d，消失时间（102．30±38．86）（35—193）d。发生Haze的患者屈光力为（-6．41±1．60）D，切削深度（87．01±14．42）μm，切削率为（0．17±0．26）；Haze的发生率随屈光度数、切削深度、切削率的增加而增加。发生Haze与未发生Haze的患者在性别、年龄、术前眼内压、是否配戴隐形眼镜及角膜中央厚度上无统计学差异。结论Epi—LASIK术后Haze发生率及密度均较低，术后是否发生Haze与屈光度数，切削深度和切削率有关。Objective To discuss the situation and predisposing factors of corneal Haze after epipolis laser in situ keratomileusis （EPI-LASIK）. Methods A total of 250 cases （ 120 men and 130 women;mean age of 22.25 years old） were included in the present series （from December 2007 to February 2008 ）, who were all outpatients in the second people＇s hospital of Jinan. Preoperative examination for all the patients included uncorrected visual acuity, best corrected visual acuity, slit-lamp findings, dilated funduscopy, subjective and cycloplegic refractions, intraocular pressure, corneal topography, and corneal thickness. The patients were all followed up for more than six months after EPI-LASIK. The time of formation and disappearance and the density of Haze were observed. The factors related to Haze were analyzed and compared. Results At six months, the overall frequency of clinically significant Haze was 33.60% ;the frequency of Haze grade 0.5 was 31.98%, grade 1 was 1.63 %. The time o f formation was 42.75 ± 23.50 （ 15-150 days ）. The time of disappearance was 102.30± 38.86 （35-193 days）. The refractive error was -6.41±1.60 D,ablation depth was 87.01± 14.42nm, the ablation depth/corneal thickness （AD/CT） ratio was 0. 17± 0.26,on which eyes Haze were found. The incidence of Haze was statistically greater with higher refractive errors, higher ablation depth and higher ablation depth/corneal thickness ratio. And no difference was found related to sex, age, intraocular pressure, corneal thickness and contact lens wear preoperatively. Conclusions There is a lower incidence and density of Haze in Epi-LASIK. Higher myopia, deeper ablation and higher ablation depth/corneal thickness ratio obviously influence the Haze formation.

关 键 词：角膜上皮下雾状混浊 屈光 近视 激光 角膜磨镶术 

分 类 号：R779.6[医药卫生—眼科] R779.63[医药卫生—临床医学]