老年性痴呆患者事件相关电位P_(300)及单胺类神经递质的关系  

A study on relation with event-ralted potential P_(300) and the serum levels of monoamine neurotransmitter with senile dementia patients

作　　者：宋景贵[1] 张宁[1] 穆俊林[1] 杨庆南[1] 顾仁骏[1] 

机构地区：[1]新乡医学院第二附属医院神经科,河南新乡453002

出　　处：《中风与神经疾病杂志》2009年第4期444-446,共3页Journal of Apoplexy and Nervous Diseases

基　　金：河南省医学科技创新人才工程项目(No.2005069)

摘　　要：目的探讨老年性痴呆(SD)患者事件相关电位(ERP)P300和单胺类神经递质的特征。方法对50例SD患者和48例正常人分别进行了ERP和血浆单胺类神经递质水平的测定,并将结果加以比较。结果SD组中ERP测定的异常率为96%(48/50),其N2、P3波潜伏期较对照组延长,P3波幅降低,差异具有统计学意义(P<0.01),血浆单胺类神经递质水平降低,与对照组相比差异具有统计学意义(P<0.01)。SD组ERP成分中P3波潜伏期与单胺类神经递质水平呈负相关(P<0.01),而P3波幅与其呈正相关(P<0.01)。结论SD患者存在血浆单胺类神经递质水平降低及认知障碍,ERP和血浆单胺类神经递质水平测定可作为老年性痴呆患者实验室判定指标应用于临床。Objective To explore the feathers on event-related potential（ERP） P300 and the serum levels of monoamine neurotransmitter with senile dementia （SD） patients. Methods ERP and the serum levels of monoamine neurotransmitter test were used on 50 SD patients and 48 normal contrals, and the results were compared. Results The abnormal rate of ERP with SD patients was 96% （48/50） ,The latency of N2 and P3 of ERP and the amplitude of P3 with SD patients group were longer and lower than those in the controls ,There were significant difference between in the two groups（ P 〈 0.01 ）. The serum levels of monoamine neurotransmitter with SD patients were signifficant lowwer than those in the contral group（P 〈0.01 ）. Correlation analysis showed that there was a remarkable negative correlation with latency of P3 of ERP and the level of monoamine neurotransmitter in SD group（P 〈0.01 ）, and a significant positive correlation with P3 amplitude respectively（P 〈 0.01 ）. Conclusion SD patients have the decrease of he serum levels of monoamine neurotransmitter and cognitive handicap, ERP and the serum levels of monoamine neurotransmitter test can be used clinical indexes to appraise SD patients.

关 键 词：老年性痴呆 事件相关电位 单胺类神经递质 

分 类 号：R742[医药卫生—神经病学与精神病学]