结肠清颗粒对溃疡性结肠炎模型大鼠血清IL-1、ICAM-1含量的影响  

Effects of Jiechangqing on IL-1 and ICAM-1 in the serum of Ulcerative Colitis Model Rats

作　　者：范立昌 薛玲[2] 王静[2] 高鲁霞[2] 

机构地区：[1]莒县人民医院药剂科,山东莒县276500 [2]山东中医药大学,山东济南250355

出　　处：《中国当代医药》2009年第12期5-6,共2页China Modern Medicine

摘　　要：目的:探讨结肠清颗粒对溃疡性结肠炎模型大鼠血清白细胞介素1(IL-1)、细胞黏附因子(ICAM-1)的影响。方法:用家兔结肠加弗氏佐剂复制大鼠溃疡性结肠炎模型,检测模型大鼠血清IL-1、ICAM-1含量。结果:结肠清颗粒能显著增加溃疡性结肠炎模型大鼠血清IL-1及ICAM-1的含量;显著降低溃疡性结肠炎模型大鼠结肠的病理改变,对模型大鼠结肠有显著的修复作用。结论:结肠清颗粒治疗溃疡性结肠炎的作用可能与其升高血清IL-1及I-CAM-1的含量,从而改善免疫功能,减轻炎症损伤有关。Objective： To study the effects of Jieehangqing granule on the Ulcerative Colitis （UC） rats. Methods： To make the Ulcerative Colitis model rats by rabbit eolon and Feud＇s adjuvant,and detected contents of IL-1 and ICAM-1 in the serum of the rats. Results： To compare with the model groups,the high-and moderate-dosage groups of Jiechangqing could up-regulated the contents of IL-1 and ICAM-1 and relieve the pathology changes significantly. Conclusion： Jiechangqing granule can up-regulated the levels of IL-1 and ICAM-1 contents in the serum of the rats ,whieh is the foundation to eure UC.

关 键 词：结肠清颗粒 溃疡性结肠炎 IL-1 ICAM-1 

分 类 号：R574.62[医药卫生—消化系统]