银耳多糖对D-半乳糖所致衰老小鼠抗氧化能力的影响  

Effect of tremella polysaccharides on the antioxidant ability of experimental aging mice

作　　者：沈卫[1] 曲丹[2] 蔡东联[1] 冯晓慧[1] 郑慧[1] 张蕾[1] 王洁[1] 连璐[1] 

机构地区：[1]青岛大学医学院中西医结合教学科研中心,266021 [2]第二军医大学长海医院营养科临床营养中心

出　　处：《中华临床营养杂志》2009年第3期158-160,共3页Chinese Journal of Clinical Nutrition

摘　　要：目的探讨银耳多糖（TP）对D-半乳糖所致衰老模型小鼠抗氧化能力的影响。方法ICR小鼠腹腔注射D-半乳糖建立衰老模型，同时给予不同剂量的TP，8周后获取小鼠心、脑，测定超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活力以及丙二醛（MDA）的含量。结果TP各剂量组SOD和GSH-Px活力显著高于对照组（P〈0．05），且高剂量TP组SOD、GSH-Px活力均高于低剂量和中剂量TP组（P〈0．05）；中、高剂量TP组MDA含量低于对照组（P〈0．05）且高剂量1]P组MDA含量低于低剂量TP组（P〈0．05）。结论TP对衰老模型小鼠抗氧化能力具有一定的正性调节作用。Objective To observe the effects of tremeUa polysaccharides （TP） on the antioxidation of experimental aging mice. Methods ICR mice were injected with D-galactose to establish subacute aging model, and then they were administered with TP at different doses. Eight weeks later the superoxide dismutase （SOD）, malondialdehyde （ MDA）, glutathione peroxidase （GSH-Px） in hearts and brains were measured and analyzed. Resuits The enzyme activities of SOD and GSH-Px in each TP group were significantly higher than in control group （P 〈 0.05）, and the enzyme activities in high-dose group were significantly higher than in middle and low-dose groups （P 〈 0.05 ）. The MDA in middle and high-dose groups was significantly lower than in control group （ P 〈 0.05 ）, and the MDA in high-dose group was significantly lower than in both middle and low group （ P 〈 0. 05 ）. Conclusion TP may improve the antioxidant ability of experimental aging mice.

关 键 词：银耳多糖 D-半乳糖 衰老 抗氧化 

分 类 号：R28[医药卫生—中药学]