TBX1基因的研究进展  

Recent Advances of TBX1 Gene

作　　者：周静怡[1] 邱广蓉[1] 孙开来[1] 

机构地区：[1]中国医科大学基础医学院医学遗传学教研室,沈阳110001

出　　处：《国际遗传学杂志》2009年第4期289-293,共5页International Journal of Genetics

基　　金：国家自然科学基金（30200305,30400405）;辽宁省教育厅科学基金（20060951,2004C045,202013133）

摘　　要：T-box家族是近年来引起国内外学者高度重视的一个转录因子家族，它们在心脏发育和遗传性疾病的发生中发挥着重要作用。TBX1转录因子在早期心脏发育，尤其是在心脏流出道的发生中起着重要作用。TBX1基因与人类22q11．2微缺失综合征的相关性是近年研究的热点问题。本文从结构特征、在胚胎发育过程中的表达、相关疾病及与其他基因的关系几方面对TBX1近几年的研究进展作一综述。T-box family causes extensive interests in recent years, which plays a critical role ifi cardiac development and hereditary disease. TBX1 transcription factor is essential for normal heart development, especially for cardiac outflow tract development. Nowadays, it is a hot research to check the relationship between TBX1 and 22q11.2 deletion syndrome. This review introduces correlation study of TBX1 in these years, including its structure characters, expression during embryonic development, correlative diseases and relationship with other genes.

关 键 词：TBX1基因 人类22q11.2微缺失综合征 精神疾病 

分 类 号：R5[医药卫生—内科学] R3[医药卫生—临床医学]