查尔酮合成方法的研究进展  

Research progress in the synthesis of chalcone

作　　者：刘翔峰[1,2] 史道华[2] 

机构地区：[1]福建中医学院药学系,福建福州350108 [2]南京军区福州总医院药学科,福建福州350025

出　　处：《应用化工》2009年第8期1210-1213,1219,共5页Applied Chemical Industry

基　　金：福建省自然科学基金项目(2008J0103);南京军区医学科学技术研究"十一五"计划课题(06MA154)

摘　　要：查尔酮是一种黄酮类化合物,其常见合成方法是以苯甲醛和苯乙酮为原料,加入碱、酸或金属等物质作为催化剂进行醛酮缩合反应,但产率较低,副产物多。近年来查尔酮化合物的合成采用了新技术,是以苯甲醛和苯乙酮为原料,BF4作为反应溶剂,水滑石为催化剂,在温度为343 K的条件下进行反应,查尔酮产率可以达到98.5%,该法具有反应时间短、操作简便、收率高等优点。分析了近年来查尔酮几种合成方法的优缺点,催化剂的选择及其适用的条件。Chalcone is a kind of flavonoids,it can be synthesized usually by benzaldehyde and acetophenone,with alkali,acid or metal material as a catalyst for condensation reaction of aldehydes and ketones, but the yield of the final product is low, and it also produces many by-products. In recent years, the new technology has been used in the synthesis of chalcone compounds, under the 343 K condition carrying on the response in the temperature. It takes benzaldehyde and acetophenone as raw material, BF4 as resolver and the hydrotalcite as the catalyst,the yield of chalcone can reach 98.5%. This method has some advantages including shorter reaction time, higher yield and simpler operation. The advantages and disadvantages, the catalyst choice and its application conditions were discussed in the chalcone synthesis.

关 键 词：查尔酮 查尔酮衍生物 合成 

分 类 号：TQ244.5[化学工程—有机化工]