重症肌无力患者血清AchR抗体和Titin抗体检测的临床意义  

Detection of serum acetylcholine receptor antibody and titin antibody in patients with myasthenia gravis and its significance

作　　者：冉娟娟[1] 古彦铮[2] 薛群[1] 王达鹏[1] 方琪[1] 

机构地区：[1]苏州大学附属第一医院神经内科,江苏苏州215006 [2]苏州大学生物技术研究所,江苏苏州215007

出　　处：《中国现代医学杂志》2009年第15期2329-2332,共4页China Journal of Modern Medicine

摘　　要：目的探讨重症肌无力患者血清AchR抗体和Titin抗体检测的临床意义。方法应用ELISA法分别检测18例重症肌无力合并胸腺瘤患者、23例非胸腺瘤重症肌无力患者、21例其他神经系统疾病患者以及26例健康献血者血清AchR抗体和Titin抗体水平。结果MG组血清AchR抗体、Titin抗体的阳性率均明显高于OND及HC两组(P<0.01),其中MGT组与NTMG组的阳性率比较差异有显著性(P<0.01);MG患者中全身型与眼肌型的两种抗体阳性率比较均差异有显著性(P<0.01);MGT组两种抗体具有显著相关性(P<0.05);两种抗体阳性率与性别均无关(P>0.05)。结论AchR抗体及Titin抗体检测可作为MG诊断的参考指标,尤其Titin抗体对合并胸腺瘤患者可能具有重要临床意义,与胸腺CT联合运用可显著提高重症肌无力合并胸腺瘤的诊断率。[Objective] To study the clinical significance of serum Acetylcholine receptor antibody（AchR-Ab） and Titin antibody（Titin-Ab） test in patients with myasthenia gravis（MG）. AchR-Ab and Titin-Ab were detected with ELISA in sera from 18 cases of MG with thymoma（MGT）, 23 cases of MG without thymoma（NTMG）, 21 cases of other neurological disease（OND） and 26 cases of health control（HC） groups. The positive rate was compared among these groups. [Results] The positive rate of AchR-Ab in MGT group was 83.3%, significantly higher than those of NTMG（21.7%）, OND group（0.0%）, HC group（0.0%）（P 〈0.01）. The positive rate of Titin-Ab in MGT group was 88.9%,significantly higher than those of NTMG（13.0%）, OND group（9.2%）, HC group（0.0%）（P 〈0.01）.The positive rate of two kinds antibodies of the systemic MG patients were higher than these of ocular MG patients （P 〈0.01）. There was a positive correlation between AchR-Ab and Titin-Ab in patients with MG. [Conclusion] Serum AchR- Ab and Titin-Ab test are helpful in diagnosis of MG,espeeially to MGT with Titin-Ab.

关 键 词：重症肌无力 AchR抗体 TITIN抗体 

分 类 号：R746.1[医药卫生—神经病学与精神病学]