血清乳酸脱氢酶在慢性淋巴细胞白血病中的研究  

Analysis of serum lactate dehydrogenase in chronic lymphocytic leukemia

作　　者：李晶波[1] 金茜[2] 房绍红[2] 于波海[2] 

机构地区：[1]哈尔滨医科大学第二临床医学院麻醉科,黑龙江哈尔滨150081 [2]哈尔滨医科大学第二临床医学院科研实验中心,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2009年第4期372-374,共3页Journal of Harbin Medical University

摘　　要：观察慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)血清乳酸脱氢酶(serum lactate dehydroge-nase,sLDH)变化及sLDH与其他预后因素的关系,以探索其对CLL诊断及预后判断的临床意义。方法检测84例CLL患者血清LDH,分析LDH与患者临床特征和ZAP-70蛋白表达的关系。结果CLL患者的血清LDH均有不同程度的升高,在ZAP-70+与LDH升高与总生存期缩短相关(P<0.05)有关,但与淋巴细胞计数、年龄和性别无关。结论检测血清LDH有助于CLL的诊断和预后评估。Objective To investigate the change of serum lactate dehydrogenase （sLDH） with other prognostic factors in patients with chronic lymphocytic leukemia（CLL）. Methods LDH were measured in 84 cases of CLL. The relationship between the enzyme level and clinical features, peripheral blood lymphocyte count, ZAP-70 were analyzed. Results The average values of LDH increased in CLL patients, ZAP-70 ＋ and high LDH were significantly associated with shorter overall survival. Conclusion Analysis of the LDH may be helpful in the diagnosis and prognosis of CLL.

关 键 词：慢性淋巴细胞白血病 乳酸脱氢酶 ZAP-70蛋白 

分 类 号：R733.72[医药卫生—肿瘤]