听觉统合训练对儿童孤独症的疗效评估  

Polymorphism of HLA-A and HLA-B in pre-eclampsia

作　　者：张改巧[1] 龚群[1] 张凤玲[1] 陈孙敏[1] 胡立群[1] 刘锋[1] 崔瑞华[1] 何琳[1] 

机构地区：[1]上海交通大学附属儿童医院儿童保健所,上海200040

出　　处：《北京大学学报（医学版）》2009年第4期426-431,共6页Journal of Peking University:Health Sciences

摘　　要：目的:探讨听觉统合训练(auditory integration training,AIT)对儿童孤独症的近期疗效,为孤独症儿童的康复治疗提供临床依据。方法:将88例孤独症患儿随机分为实验组和对照组,两组均进行综合治疗,实验组在其基础上进一步行AIT治疗,疗效评估主要采用韦氏幼儿(或儿童)智力测验(WPPSI或WISC-R)或Gesell量表、孤独症儿童行为检查量表(Autism Behavior Checklist,ABC)等方法,对患儿进行治疗前后临床症状、ABC分值及智商(in-telligence quotient,IQ)分值变化的比较。结果:有7例患儿失访。实验组经过AIT治疗6个月后,与对照组比较,患儿在语言障碍、社会交往障碍、某些行为特征方面有明显的改善(P<0.05);但在异常行为方面两组比较差异无统计学意义。实验组IQ明显提高、ABC分值明显降低,两组之间差异有统计学意义(P<0.05)。ABC分值下降的程度和IQ分值升高程度与患儿年龄呈负相关;ABC分值下降的程度与患儿基础智商呈正相关。结论:AIT可以改善孤独症患儿的语言障碍、社会交往障碍、某些行为特征和发育水平,其对儿童孤独症的近期疗效比较肯定。Objective：To explore the short-term treatment effect of the auditory integrative training on autistic children and provide them with clinical support for rehabilitative treatment. Methods： A total of 81 cases of autistic children were selected through the standard of DSM-4 and clinical case study was used. They were divided randomly into experimental group and control one, and respectively received auditory integrative training and no training based on the multiple therapies. The patients were investigated using clinical manifestation and Autism Behavior Checklist （ABC） and intelligence quotient （IQ） before and after six months of treatment. The effect was evaluated through the changes of clinical manifestations and scores of ABC and IQ. The changes of scores of IQ were determined with Gesell and WPPSI or WISC-R. Results： Compared with 40 patients of the control group after the six months of the auditory integrative training, 41 of the experimental group had greatly improved in many aspects, such as the disorders of their language, social interactions and typical behavior symptoms while they had not changed in their abnormal behaviors. The scores of IQ or DQ had increased and scores of ABC had dropped. The differences between the two groups were greatly significant in statistics （P 〈 0. 01 ）. The decreasing level of both ABC scores and the increasing level of the IQ scores were negatively correlated with age, and the decreasing level of ABC scores was in line regression （ positive correlation） with base IQ. Conclusion ： The treatment of auditory integrative training（AIT） could greatly improve on language disorders, the difficulties of social interactions, typical behavior symptoms and developmental levels, therefore it is positive to the autistic children in its short-term treatment effect.

关 键 词：音乐疗法 孤独性障碍 治疗结果 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]