牙周炎症对冠心病患者CRP水平影响的初探  

Effect of periodontal inflammation on serum CRP levels in patients with coronary heart disease

作　　者：周卉[1,2] 欧阳翔英[1] 段晋瑜[1] 段向青[3] 

机构地区：[1]北京大学口腔医学院.口腔医院牙周科,100081 [2]北京大学口腔医院第二门诊部 [3]北京安贞医院

出　　处：《北京口腔医学》2009年第4期214-216,219,共4页Beijing Journal of Stomatology

基　　金：国家自然科学基金(30471883);十一五科技支撑计划(2007BAZ18B02)

摘　　要：目的通过横向研究初步探讨牙周炎症对冠心病患者CRP水平的影响。方法受检者共60人,包括冠心病+牙周炎组、单纯牙周炎组和健康对照组,每组20人。检测超敏C反应蛋白(hs-CRP),牙周临床指标包括牙周探诊深度、附着丧失、出血指数、菌斑指数,并检测血脂水平(HDL、LDL、TG、CHO)和白细胞计数。采用ANOVA法分析以上指标在各组间的差别,Pearson法分析hs-CRP与牙周指标间的相关性。结果牙周炎+冠心病组hs-CRP显著高于单纯牙周炎组和健康组(P<0.05),单纯牙周炎组的hs-CRP水平又显著高于健康组(P<0.05)。牙周炎+冠心病组牙周指标均高于单纯牙周炎组和健康组。受检者的血清hs-CRP水平与牙周指数显著相关(P<0.05)。结论牙周感染和炎症可能是牙周炎+冠心病患者hs-CRP水平升高的原因之一。Objective To investigate the effect of periodontal inflammation on serum-CRP levels in patients with coronary heart disease. Methods Sixty subjects were enrolled in this study, including 20 patients with coronary heart disease and chronic periedontitis （CHD ＋ CP）, 20 patients with chronic periodontitis （CP）, 20 healthy controls （H）. Clinical periodontal parameters including probing depth （ PD ） , attachment loss （AL） , bleeding index （ BI ） and plaque index （PLI） were examined. Hs-CRP, HDL, LDL, TG, CHO, and WBC count were tested. Differences in periodontal parameters,hs-CRP levels and lipid levels among the three groups were analyzed by ANOVA. Correlations of CRP with periodontal parameters were analyzed by Pearson correlation. Results Hs-CRP levels of CP ＋ CHD group were significantly higher than that of CP group and H group （ P 〈 0. 05 ）. Hs-CRP levels in group CP were higher than in group H. The average PD, AL, BI, PLI were elevated in group CP ＋ CHD than in group CP and group H （ P 〈 0. 05 ）. Hs-CRP levels were significantly correlated to PD, BI and PLI. Conclusion Periodontal infection and inflammation might be one of the reasons for the increased hs-CRP in patients with coronary heart disease and chronic periodontitis.

关 键 词：牙周炎症 冠心病 超敏C反应蛋白 

分 类 号：R781.42[医药卫生—口腔医学]