局部晚期非小细胞肺癌时辰放疗的疗效观察  

THERAPEUTIC EFFECT OF CHRONORADIOTHERAPY FOR LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER

作　　者：别俊 李光明 文世明 任大成 胡欣 付曦 

机构地区：[1]四川省南充市中心医院肿瘤防治中心,南充637000

出　　处：《现代预防医学》2009年第15期2956-2957,共2页Modern Preventive Medicine

基　　金：四川省卫生厅科研项目(050246)

摘　　要：[目的]观察时辰放疗治疗局部晚期非小细胞肺癌(NSCLC)的疗效和毒副反应。[方法]60例局部晚期非小细胞肺癌患者随机分两组,时辰组31例予时辰放疗,对照组29例予后程三维适形放疗,两组均采用相同放疗方法和剂量。不同之处在于时辰放疗组时间设在20:00～22:00,对照组时间定在8:00～10:00。放疗结束后3个月评价近期疗效。[结果]时辰放疗组有效率(CR+PR)为77.4%(24/31),对照组有效率为(CR+PR)为51.7%(15/29),两组有效率比较,差异有统计学意义(P﹤0.05),主要不良反应为放射性食管炎及放射性肺炎,时辰放疗组较对照组低(P﹤0.05),两组生存时间比较,差异无统计学意义(P﹥0.05)。[结论]时辰放疗可提高局部晚期非小细胞肺癌疗效,毒副反应低,值得临床进一步研究。To evaluate the efficacy and toxicity of Chrono-radiotherapy for locally advanced non-small cell lung cancer（NSCLC）. [Methods] 60 cases of NSCLC patients were randomly divided into two groups, including chrono-radio-therapy group （N=31） and late course conformal radiotherapy group （N=29） . Same radiotherapies and dosages were administered to the two groups, but treatment time was different： chrono-radiotherapy were determined from 20： 00 to 22： 00; and the control groups were determined from 8： 00 to 10： 00. The therapeutic effect was evaluated after chrono-radiotherapy. [Results] The total response rates （CR＋PR） in chrono-radiotherapy group and control group were 77.4% and 51.7% , respectively. There was significant difference between the two groups （P﹤0.05）. The main adverse events of radiotherapy were radioactive esophagitis and radioactive pneumonia, and the rate of adverse events in chrono-radiotherapy group was lowed than that in control group. There was difference between the two groups （P﹥0.05）. [Conclusion] The chrono-radiotherapy is more effective than late course conformal radiotherapy for locally advanced NSCLC, and has lower side effects as well. The chrono-radiotherapy needs further studies in clinic.

关 键 词：局部晚期 非小细胞肺癌 时辰放疗 后程适形放疗 

分 类 号：R734.2[医药卫生—肿瘤]