脑梗死患者颈动脉粥样硬化斑块和血浆基质金属蛋白酶3的相关性研究  

The Relationship between Carotid Artery Plaque and Matrix Metalloproteinases-3 in Patients with Cerebral Infarction

作　　者：俞龙[1] 吴健[1] 刘筱洁[1] 徐燕萍[1] 陈勇[1] 

机构地区：[1]扬州大学附属江苏省苏北人民医院神经内科,262700

出　　处：《中国医药指南》2009年第16期5-7,共3页Guide of China Medicine

基　　金：江苏省扬州市科委立项项目;江苏省扬州市社会发展计划项目:Wb20052021

摘　　要：目的研究脑梗死患者颈动脉内膜中层厚度(IMT)及斑块发生率和血浆基质金属蛋白酶3(MMP-3)的血浆水平及二者的相关性。方法用彩色多普勒超声检测80例脑梗死患者和30例健康对照组颈动脉IMT及斑块,脑梗死组根据斑块的性质,分为三组:颈动脉软斑组(n=39)、颈动脉硬斑组(n=24)、无斑块组(n=17),用ELISA法测定血桨MMP-3。结果与对照组相比,脑梗死组比对照组的三酰甘油、总胆固醇、低密度脂蛋白胆固醇的水平偏高,而高密度脂蛋白胆固醇则降低,有显著差异(P<0.05),脑梗死组的颈动脉IMT明显高于对照组,其斑块发生率亦明显高于对照组,有显著差异(P<0.05),MMP-3的血浆水平在脑梗死组明显高于对照组,其中伴有颈动脉软斑及混合斑的脑梗死组明显升高,与颈动脉硬斑、无斑块的脑梗死组和正常对照组比较有显著差异(P<0.05),而无斑块的脑梗死组和正常对照组比较无显著差异(P>0.05)。结论血浆MMP-3水平的提高和颈动脉IMT及斑块的不稳定性及脑梗死的形成有着密切联系。Objective To study the intima-media thickness 0MT）, plaque of the carotid artery and matrix metalloproteinase-3 （MMP-3） in patients with cerebral infarction and the relationship between MMP-3 and the carotid IMT and plaque. Methods Using high resolution ultrasonic instrument, IMT and the plaque in the carotid artery were detected in 80 patients with cerebral infarction, 39 patients with soft carotid plaques, and 24 patients with hard carotid plaques, and 17 eases without carotid atherosclerosis. Serum concentration of MMP-3 was measured by enzyme linked immunoadsorbent assay （ELISA）. Results Compared with control group, IMT, plaque in the carotid artery in patients with cerebral infarctiona significantly increased （P〈0.05）. MMP-3 in patients with cerebral infarction were significantly increased （P〈0.05） as compared with that in control group. Conclusion There may be a close relationship between serum. level of MMP-3 with pathogeny and the induction of disruption of arteriosclerosis plaque. MMP-3 play an important role in cerebral infarction.

关 键 词：脑梗死 粥样硬化斑块 颈动脉 内膜中层厚度 基质金属蛋白酶3 

分 类 号：R743.33[医药卫生—神经病学与精神病学]