肾癌预后与浸润肥大细胞、淋巴细胞和P53表达的关系  

A study of infiltrating mast cell and lymphocyte and of P53 expression in renal cell carcinoma

作　　者：南勋义[1] 张冠军[1] 张学斌[1] 党建功[1] 贺大林[1] 陈兴发[1] 

机构地区：[1]西安医科大学第一附属医院泌尿外科

出　　处：《中华泌尿外科杂志》1998年第8期480-482,共3页Chinese Journal of Urology

摘　　要：对４３例肾癌中长期存活（＞５年）组２１例和短期转移组２２例分别进行了癌间质中肥大细胞数量、淋巴细胞反应程度以及Ｐ５３蛋白表达研究。结果证明长存组肾癌交界区及中心区肥大细胞计数明显高于转移组（Ｐ＜００１），且交界区计数高于中心区。长存组癌间质淋巴细胞反应强于转移组（Ｐ＜００１），其反应程度与肥大细胞计数有明显正相关性。Ｐ５３蛋白表达在两组间无显著性差异（Ｐ＞００５）。前两者反应强时，患者生存期延长、预后亦好。提示癌间质肥大细胞数量。P53 expression and infiltrating mast cells and lymphocytes were studied in tissue sections of 43 cases of renal cell carcinoma.The patients consisted of 2 groups,those with a longsurvival of more than 5 years and those with metastasis shortly after surgical intervention.The result revealed that the infiltrating mast cells and lymphocytes in either marginal or central zone of the tumor were significantly more in the long survival group.A positive correlation has been observed between the number of mast cells and the degree of lymphocytic infiltration.There was no significant difference of P53 expression between the 2 groups of patients.The result denoted that the quantitative study of mast cell and lymphocyte might be of importance in the prognosis of renal cell carcinoma.

关 键 词：肾肿瘤 肥大细胞 淋巴细胞 P53基因 预后 

分 类 号：R737.110.7[医药卫生—肿瘤]