体质指数与结肠癌的关系探讨  

Relationship between body mass index and colon cancer

作　　者：郑美春[1,2] 孔令亨[1,2] 卢震海[1,2] 方淯靖[1,2] 潘志忠[1,2] 朱亚萍[1,2] 温咏珊[1,2] 万德森[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心结直肠科,广东广州510060

出　　处：《癌症》2009年第9期928-931,共4页Chinese Journal of Cancer

摘　　要：背景与目的:肥胖被证实为增加结直肠癌的重要因素。有研究表明,无论对于男性还是女性,体质指数(body mass index,BMI)都与结肠癌的发病率有密切关系。因此,本研究探讨BMI与我国结肠癌发病的关系,为结肠癌的预防提供参考。方法:用病例-对照研究方法分析707例首次确诊的结肠癌患者和709名健康人的BMI情况,比较两组人群BMI的情况。结果:首次确诊的结肠癌患者平均BMI为(24.52±4.56)kg/m2,健康对照人群平均BMI为(23.75±3.14)kg/m2,结肠癌患者的BMI明显高于健康对照人群(t=-3.72,P<0.001)。根据性别和年龄的不同进行分组后,可以看出结肠癌患者的BMI比健康对照组高。logistic回归分析,BMI的升高是结肠癌发生的危险因素,OR值为1.059(95%CI,1.029～1.090)。结论:汉族人结肠癌的发生与BMI有关。Background and Objective： Obesity is associated with increased risk of colorectal cancer. Many studies showed that body mass index （BMI） is related to the incidence of colon cancer. This study was to explore the relationship between BMI and colon cancer in Chinese population and provide evidences for the prevention of colon cancer. Methods： Clinical data, including BMI, of 707 colon cancer patients and 709 healthy subjects were compared. Results： The mean BMI was significantly higher in colon cancer patients than in healthy subjects [（24.52±4.56） kg/m^2 vs. （23.75±3.14） kg/ m^2, t=-3.72, P〈0.001 ]. When stratified by sex and age, the BMI was always higher in colon cancer patients than in healthy subjects. Logistic regression analyses showed that BMI was an important risk factor of colon cancer （odds ratio =1.059, 95% confidence interval =1.029-1.090）. Conclusion： The occurrence of colon cancer in Chinese population is related to BMI.

关 键 词：结肠肿瘤 危险因素 体质指数 

分 类 号：R735.35[医药卫生—肿瘤]