代谢组学在肝脏疾病研究中的应用进展  

The prospect of metabonomics＇ application in liver diseases

作　　者：郭永征[1] 李兰娟[1] 

机构地区：[1]浙江大学医学院附属第一医院传染内科,传染病诊治国家重点实验室,杭州310003

出　　处：《国际流行病学传染病学杂志》2009年第4期244-247,共4页International Journal of Epidemiology and Infectious Disease

基　　金：国家863计划（H40803）;国家自然科学基金重点项目（30630023）

摘　　要：代谢组学是通过考察生物体受到来自体内外的各种刺激或扰动时内源性小分子代谢物所发生的变化。来阐明生物体系的代谢途径的一种较新的组学技术。肝脏作为生物体最大、最复杂的代谢器官，参与了体内绝大部分的代谢过程。肝脏病变时，其相关的代谢网络必然会发生相应的变化。近几年，代谢组学技术在肝脏疾病研究中的应用日益增多，此文对代谢组学的概念、研究现状、研究方法及在肝脏疾病的基础和临床研究中的应用进行综述。Following the sequencing of the human and other genomes, much research effort is now invested in post, genomic science. Metabonomics, defined as the systematic study of small-molecular-weight substances in cells, tissues and/or whole organisms as influenced by multiple factors, including genetic alterations, pathophysicological stimuli, pharmaceutical interventions, diet, lifestyle or environmental influences, is a novel methodology arising from the post-genomics era for the study of molecular systems biology. These substances may directly or indirectly interact with molecular targets and thereby influence the risk and complications associated with various diseases, including liver diseases. Consequently, the comprehensive and quantitative study of the changed, endogenous metabolites, or metabolomies, will be helpful in the discovery of the liver diseases＇ phynotype. In this article, metabonomic concept and research techniques and its application in liver disease researches are reviewed.

关 键 词：肝疾病 代谢组学 方法 

分 类 号：R575[医药卫生—消化系统]