亲代谢型谷氨酸受体和相关神经疾病  

Metabotropic glutamate receptors and related nervous diseases

作　　者：龙锐[1] 杜俊蓉[2] 

机构地区：[1]重庆医科大学附属第一医院药剂科,重庆400016 [2]四川大学华西药学院药理学教研室,四川成都610041

出　　处：《中国药理学通报》2009年第8期998-1001,共4页Chinese Pharmacological Bulletin

摘　　要：谷氨酸的过量释放在多种神经系统疾病的发生发展过程中发挥着重要作用。虽然离子型谷氨酸受体拮抗剂在动物模型中取得了一定的治疗效果,但因其同时阻断了正常的兴奋性传递,限制了这类化合物的临床应用;而mG luR s通过突触前机制抑制谷氨酸的释放,有望成为某些神经系统疾病治疗的新靶点。该文就近年来国内外mG luR s在这些神经疾病中的研究进展作一综述。Excessive release of glutamic acid plays an important role in the occurring and development of many nervous system diseases. Ionotropic glutamate receptors antagonists are shown to have therapeutic effect in animal models, but their clinical application is limited by their effects of blocking the normal excitatory neurotransmission. However, metabotropic glutamate receptors can suppress the release of glutamic via presynaptic mechanisms, which makes them the new targeting points of certain nervous system disease. This paper reviews the recent research progress of mGluRs in nervous diseases both at home and abroad.

关 键 词：谷氨酸 亲代谢型谷氨酸受体 神经疾病 癫痫 帕金森 缺血性脑中风 疼痛 

分 类 号：R-05[医药卫生] R392.11